OncoMatch/Clinical Trials/NCT05646316
Impact of Sentinel Lymph Node Mapping on Patient Reported Lower Extremity Limb Dysfunction in Stage I Endometrial Cancer
Is NCT05646316 recruiting? Yes, currently enrolling (May 2026). This Phase 3 trial studies Indocyanine Green Solution for stage i uterine corpus carcinoma or carcinosarcoma ajcc v8.
Treatment: Indocyanine Green Solution — This phase III trial compares the effect of sentinel lymph node mapping to standard lymph node dissection in reducing the risk of swelling in the legs (lymphedema) in patients undergoing a hysterectomy for stage I endometrial cancer. Standard lymph node dissection removes lymph nodes around the uterus during a hysterectomy to look for spread of cancer from the uterus to nearby lymph nodes. Sentinel lymph node mapping uses a special dye and camera to look for cancer that may have spread to nearby lymph nodes. Comparing the results of the procedures may help doctors predict the risk of long-term swelling in the legs.
Check if I qualifyExtracted eligibility criteria
Disease stage
Required: Stage I
Performance status
ECOG 0–2(Ambulatory, capable of self-care)
Prior therapy
Cannot have received: chemotherapy
Exception: progestin-containing therapies such as megestrol, medroxyprogesterone, or levonorgestrel-containing intrauterine device (IUD) are acceptable
History of chemotherapy or immunotherapy for the treatment of endometrial cancer. Progestin-containing therapies such as megestrol, medroxyprogesterone, or levonorgestrel-containing intrauterine device (IUD) are acceptable
Cannot have received: immunotherapy
Exception: progestin-containing therapies such as megestrol, medroxyprogesterone, or levonorgestrel-containing intrauterine device (IUD) are acceptable
History of chemotherapy or immunotherapy for the treatment of endometrial cancer. Progestin-containing therapies such as megestrol, medroxyprogesterone, or levonorgestrel-containing intrauterine device (IUD) are acceptable
Cannot have received: radiation therapy
History of radiation to the pelvis, groin or lower extremities
Cannot have received: surgery
surgery to the pelvic lymph nodes or inguinal lymph nodes
Structured fields extracted by AI. May contain errors — verify against the official protocol.
US trial sites
- George Washington University Medical Center · Washington D.C., District of Columbia
- UM Sylvester Comprehensive Cancer Center at Coral Gables · Coral Gables, Florida
- UM Sylvester Comprehensive Cancer Center at Deerfield Beach · Deerfield Beach, Florida
- UM Sylvester Comprehensive Cancer Center at Doral · Doral, Florida
- University of Miami Miller School of Medicine-Sylvester Cancer Center · Miami, Florida
Showing up to 5 US sites. See all sites on ClinicalTrials.gov →
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