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OncoMatch/Clinical Trials/NCT05643742

A Safety and Efficacy Study Evaluating CTX112 in Subjects With Relapsed or Refractory B-Cell Malignancies

Is NCT05643742 recruiting? Yes, currently enrolling (May 2026). This Phase 1/2 trial studies CTX112 for b-cell lymphoma.

Phase 1/2RecruitingCRISPR Therapeutics AGNCT05643742Data as of May 2026

Treatment: CTX112This is an open-label, multicenter, Phase 1/2 study evaluating the safety and efficacy of CTX112™ in subjects with relapsed or refractory B-cell malignancies.

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Extracted eligibility criteria

Cancer type

Non-Hodgkin Lymphoma

Chronic Lymphocytic Leukemia

Diffuse Large B-Cell Lymphoma

Performance status

ECOG 0–1(Restricted strenuous activity)

Prior therapy

Cannot have received: allogeneic hematopoietic stem cell transplant

Lab requirements

Kidney function

adequate renal function

Liver function

adequate liver function

Cardiac function

adequate cardiac function

Adequate renal, liver, cardiac and pulmonary organ function

Structured fields extracted by AI. May contain errors — verify against the official protocol.

US trial sites

  • Washington University · St Louis, Missouri
  • SCRI · San Antonio, Texas
  • University of Utah · Salt Lake City, Utah
  • University of Kansas · Westwood, Kansas

Showing up to 5 US sites. See all sites on ClinicalTrials.gov →

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