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OncoMatch/Clinical Trials/NCT05636111

Phase 1b of Lurbinectedin in Combination With Weekly Paclitaxel and Bevacizumab in Platinum-resistant Ovarian Cancer

Is NCT05636111 recruiting? Yes, currently enrolling (May 2026). This Phase 1 trial studies multiple treatments including Paclitaxel and Bevacizumab for ovarian cancer.

Phase 1RecruitingM.D. Anderson Cancer CenterNCT05636111Data as of May 2026

Treatment: Paclitaxel · Bevacizumab · LurbinectedinTo learn if adding lurbinectedin to the combination of paclitaxel and bevacizumab can help to control advanced cancer.

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Extracted eligibility criteria

Cancer type

Ovarian Cancer

Performance status

ECOG 0–1(Restricted strenuous activity)

Prior therapy

Cannot have received: any anticancer therapy

Exception: adjuvant/neoadjuvant therapy permitted if completed >2 weeks before cycle 1 day 1

Radiation, chemotherapy, or immunotherapy or any other anticancer therapy ≤2 weeks prior to cycle 1 day 1

Cannot have received: investigational drug

Use of an anti-cancer treatment drug or investigational drug during the last 28 days or 5 half-lives (whichever is shorter) prior to cycle 1 day 1. A minimum of 10 days between termination of prior treatment and administration of study treatment is required.

Cannot have received: investigational anti-cancer study

Participation in an investigational anti-cancer study within 3 weeks prior to Cycle 1 Day 1

Cannot have received: concurrent anticancer therapy

Exception: steroids allowed

Concurrent therapy with approved or investigational anticancer therapeutic other than steroids.

Lab requirements

Blood counts

Hemoglobin ≥9.0 g/dL; ANC >1500/mm3; Platelet count ≥100 x 10^9/L

Kidney function

Measured or calculated creatinine clearance >40 mL/min (Cockcroft-Gault or 24-hour urine collection)

Liver function

Serum bilirubin ≤1.5 x ULN (Gilbert's syndrome exception); AST (SGOT)/ALT (SGPT) ≤2.5 x ULN unless liver metastases are present, in which case ≤5x ULN.

Cardiac function

Unstable cardiovascular function excluded: ECG abnormalities requiring treatment, CHF NYHA Class ≥3, MI within 3 months

Adequate normal organ and marrow function as defined below. Unstable cardiovascular function: ECG abnormalities requiring treatment, or congestive heart failure (CHF) of NYHA Class ≥3, or myocardial infarction (MI) within 3 months.

Structured fields extracted by AI. May contain errors — verify against the official protocol.

US trial sites

  • M D Anderson Cancer Center · Houston, Texas

Showing up to 5 US sites. See all sites on ClinicalTrials.gov →

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