OncoMatch/Clinical Trials/NCT05631249
Sotorasib in Previously Treated Locally Advanced or Metastatic NSCLC Subjects With Mutated KRAS p.G12C
Is NCT05631249 recruiting? Yes, currently enrolling (May 2026). This Phase 2 trial studies Sotorasib 120Mg Tab for kras p.g12c.
Treatment: Sotorasib 120Mg Tab — This study aims to provide a comprehensive understanding of sotorasib's mechanisms of action and resistance in NSCLC patients.
Check if I qualifyExtracted eligibility criteria
Cancer type
Small Cell Lung Cancer
Biomarker criteria
Required: KRAS G12C mutation
KRAS p.G12C mutation confirmed through molecular testing (results of both tissue and liquid biopsy are accepted)
Performance status
ECOG 0–1(Restricted strenuous activity)
Prior therapy
Cannot have received: kras inhibitor
Lab requirements
Blood counts
adequate bone marrow reserve and organ function, based on local laboratory data within 14 days prior to registration
Kidney function
adequate organ function, based on local laboratory data within 14 days prior to registration
Liver function
adequate organ function, based on local laboratory data within 14 days prior to registration
Have adequate bone marrow reserve and organ function, based on local laboratory data within 14 days prior to registration
Structured fields extracted by AI. May contain errors — verify against the official protocol.
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