OncoMatch/Clinical Trials/NCT05629494
Anti-inflammatory Drugs and Serum Prostate-Specific Antigen Test
Is NCT05629494 recruiting? Yes, currently enrolling (May 2026). This Phase 4 trial studies Ibuprofen 400 mg, TID for prostate cancer.
Treatment: Ibuprofen 400 mg, TID — Prostate cancer is the most frequently diagnosed cancer in men in the Unites States. Nearly 1 million prostate biopsy procedures are performed in the United States annually and elevated prostate-specific antigen (PSA) level is the primary reason for prostate biopsy in \> 90% of cases. However, at the PSA levels which trigger prostate biopsy, often no cancer is found in prostate biopsy specimens. PSA test can be elevated due to reasons other than cancer such as inflammation or natural variation in the level. Investigators plan to treat men with elevated PSA level with over the counter anti-inflammatory medications (ibuprofen, naproxen) to see if the PSA level will decrease to an acceptable level.
Check if I qualifyExtracted eligibility criteria
Cancer type
Prostate Cancer
Prior therapy
Cannot have received: 5-alpha reductase inhibitor (finasteride, dutasteride)
Exception: unless patient has been taking it for at least 6 months
Concomitant use of 5-alpha reductase inhibitors (finasteride, dutasteride) unless patient has been taking it for at least 6 months
Cannot have received: anti-inflammatory or steroidal drugs
Concomitant anti-inflammatory or steroidal drugs
Cannot have received: dual-antiplatelet or anticoagulant therapy
Exception: except aspirin 81 mg alone
Concomitant dual-antiplatelet or anticoagulant therapy use except aspirin 81 mg alone
Lab requirements
Kidney function
No severe chronic kidney disease: eGFR < 30 mL/min/1.73 m2
Liver function
No severe liver disease (abnormal liver function tests: AST or ALT > 3X ULN)
Cardiac function
No heart failure, significant heart disease, or poorly controlled hypertension
Known severe chronic kidney disease: eGFR < 30 mL/min/1.73 m2; Know history of severe liver disease determined by abnormal liver function tests (elevated AST or ALT > 3X ULN based on exiting history or labs); Heart failure, significant heart disease; Poorly controlled hypertension
Structured fields extracted by AI. May contain errors — verify against the official protocol.
US trial sites
- University of Chicago Medical Center · Chicago, Illinois
- Albany Medical Center · Albany, New York
- Penn State-Hershey Medical Center · Hershey, Pennsylvania
Showing up to 5 US sites. See all sites on ClinicalTrials.gov →
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