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OncoMatch/Clinical Trials/NCT05617716

Spine Radiosurgery for Symptomatic Metastatic Neoplasms

Is NCT05617716 recruiting? Yes, currently enrolling (May 2026). This Phase 2 trial studies non-drug interventions for metastatic neoplasm to the spine.

Phase 2RecruitingUniversity of OklahomaNCT05617716Data as of May 2026

The purpose of this study is to compare three types of radiation therapy for cancer that has spread to the spine. The two types of radiation therapy used in this trial are External Beam Radiation Therapy (EBRT) and Stereotactic Body Radiation Therapy (SBRT). EBRT delivers tightly targeted radiation beams from outside the body. SBRT is a specialized type of radiation therapy that allows high doses of radiation to small targets. This study will include standard dose SBRT and higher dose SBRT. Each participant will be randomly assigned to either EBRT, standard dose SBRT, or higher dose SBRT.

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Extracted eligibility criteria

Disease stage

Metastatic disease required

Prior therapy

No prior treatment (treatment-naive required)
Max 0 prior lines

Cannot have received: radiation therapy (Pluvicto)

Prior therapy includes previous radiation therapy encompassing the anatomic site to be treated with spine SBRT. This includes any previous radiation therapy where the treatment field overlaps with the anatomic site to be treated with spine SBRT (even if that previous radiation therapy was not for treatment of spinal disease). Systemic radiation therapy for metastatic disease such as Pluvicto also counts as previous radiation therapy.

Cannot have received: stereotactic radiosurgery

Participant has received previous stereotactic radiosurgery where the 50% isodose line overlaps with current treatment field

Cannot have received: spinal surgical procedure

Exception: biopsy is not considered a previous spinal surgical procedure

Participant has received previous spinal surgical procedure involving the SBRT target volume. Biopsy is not considered a previous spinal surgical procedure.

Structured fields extracted by AI. May contain errors — verify against the official protocol.

US trial sites

  • Johns Hopkins University Hospitals · Baltimore, Maryland
  • OU Health Stephenson Cancer Center · Oklahoma City, Oklahoma

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