OncoMatch/Clinical Trials/NCT05592015
Ruxolitinib for the Treatment of T-Cell Large Granular Lymphocytic Leukemia
Is NCT05592015 recruiting? Yes, currently enrolling (Jun 2026). This Phase 2 trial studies Ruxolitinib for t-cell large granular lymphocyte leukemia.
Treatment: Ruxolitinib — This phase II trial tests whether ruxolitinib works to shrink tumors in patients with T-cell large granular lymphocyte leukemia. Ruxolitinib may stop the growth of cancer cells by blocking some of the enzymes needed for cell growth.
Check if I qualifyExtracted eligibility criteria
Treatments studied
Targeted therapy
Cancer type
Non-Hodgkin Lymphoma
Performance status
ECOG 0–2(Ambulatory, capable of self-care)
Prior therapy
Lab requirements
Blood counts
Platelet count > 50 x 10^9/L (transfusion permitted if >50,000/uL within 5 days of last transfusion); ANC >= 100/mm^3 (G-CSF permitted if ANC remains above 100/mm^3 for 5 days after last growth-factor)
Kidney function
Serum creatinine <= 2 x ULN; eGFR >= 30 mL/min (MDRD equation); Platelets <100 x 10^9/L and renal impairment (CrCl < 90 mL/min) not permitted
Liver function
Total bilirubin <= 1.5 x ULN (patients with Gilbert's syndrome with a bilirubin > 1.5 x ULN permitted); AST and ALT <= 2.5 x ULN; ALP <= 2.5 x ULN
Platelet count > 50 x 10^9/L...Serum creatinine <= 2 x ULN...eGFR >= 30 mL/min...Total bilirubin <= 1.5 x ULN (patients with Gilbert's syndrome with a bilirubin > 1.5 x ULN permitted)...AST and ALT <= 2.5 x ULN...ALP <= 2.5 x ULN
Structured fields extracted by AI. May contain errors — verify against the official protocol.
US trial sites
- Dana-Farber Cancer Institute · Boston, Massachusetts
- Memorial Sloan Kettering Cancer Center · New York, New York
- Ohio State University Comprehensive Cancer Center · Columbus, Ohio
Showing up to 5 US sites.
See all sites on ClinicalTrials.gov →Frequently asked questions
Is NCT05592015 currently recruiting?
Yes, this trial is currently recruiting patients.
Could you qualify for this trial?
Enter your biomarker results to see how this trial's eligibility criteria match your specific cancer profile.
Check if I qualifyRelated pages