OncoMatch/Clinical Trials/NCT05583071
Methotrexate, Tafasitamab, Lenalidomide and Rituximab in Patients With PCNSL
Is NCT05583071 recruiting? Yes, currently enrolling (Jun 2026). This Phase 2 trial studies multiple treatments including Tafasitamab and Lenalidomide for non-hodgkin lymphoma.
Treatment: Tafasitamab · Lenalidomide · Rituximab · Methotrexate — Pilot-trial of Methotrexate, Tafasitamab (Minjuvi®), Lenalidomide (Revlimid®) and Rituximab in patients ineligible for HCT-ASCT with Primary Central Nervous System Lymphoma (PCNSL)
Check if I qualifyExtracted eligibility criteria
Treatments studied
Immunotherapy
Chemotherapy
Endocrine / hormonal
Other
Cancer type
Non-Hodgkin Lymphoma
Demographics
Prior therapy
Cannot have received: any treatment for PCNSL
Exception: pre-phase treatment comprising steroid treatment and/or single application of rituximab 375 mg/m² and methotrexate 3.5 g/m²
Prior treatment for PCNSL with the exception of a pre-phase treatment comprising steroid treatment and / or single application of rituximab 375 mg/m² and methotrexate 3.5 g/m²
Lab requirements
Blood counts
white blood cell (wbc) count ≥ 3000/µl or absolute neutrophil count (anc) ≥ 1000/µl; platelets ≥ 50.000/µl; hemoglobin > 8.0 g/dl
Kidney function
serum creatinine estimated glomerular filtration rate (mdrd) ≥ 50 ml/min
Liver function
alat and asat ≤ 3 uln; bilirubin ≤ 2.0 mg/dl (except for meulengracht disease)
Cardiac function
cardiac ejection fraction ≥ 40%
Structured fields extracted by AI. May contain errors — verify against the official protocol.
Frequently asked questions
Is NCT05583071 currently recruiting?
Yes, this trial is currently recruiting patients.
Can patients have received prior systemic therapy?
No. This trial requires treatment-naive patients — prior systemic therapy is an exclusion criterion.
Is there an age limit?
Yes. Patients must be 99 years or younger.
Could you qualify for this trial?
Enter your biomarker results to see how this trial's eligibility criteria match your specific cancer profile.
Check if I qualifyRelated pages