OncoMatch/Clinical Trials/NCT05556473
F-Tryptophan PET/CT in Human Cancers
Is NCT05556473 recruiting? Yes, currently enrolling (May 2026). This Phase 1 trial studies 1-(2-[18F]FLUOROETHYL)-L-Tryptophan for intracranial glioma.
Treatment: 1-(2-[18F]FLUOROETHYL)-L-Tryptophan — Imaging procedures such as 1-(2-\[18F\]FLUOROETHYL)-L-Tryptophan PET/CT in patients with cancers may help doctors assess a patient's response to treatment and help plan the best treatment in the future. The purpose is to see if there can be a better differentiation of tumor and non-tumor tissue where the tumor tissue has a higher uptake of Tryptophan.
Check if I qualifyExtracted eligibility criteria
Cancer type
Glioblastoma
Breast Carcinoma
Neuroendocrine Tumor
Colorectal Cancer
Disease stage
Metastatic disease required
Metastatic Brain Tumor
Performance status
ECOG 0–2(Ambulatory, capable of self-care)
Prior therapy
Cannot have received: tumor surgery
Tumor surgery or radiation within 1 month prior to the PET scan
Cannot have received: radiation therapy
Tumor surgery or radiation within 1 month prior to the PET scan
Cannot have received: tumor-directed therapy
Tumor-directed therapy within 3 months to the area of planned imaging.
Cannot have received: targeted agent (sunitinib, everolimus)
Ongoing treatment with a targeted agent (e.g., sunitinib or everolimus)
Cannot have received: cytotoxic chemotherapy (capecitabine, temozolomide)
receiving cytotoxic chemotherapy (e.g., capecitabine or temozolomide)
Cannot have received: tryptophan-hydroxylase inhibitor (telotristat ethyl)
Use of telotristat ethyl (a tryptophan-hydroxylase inhibitor) within one month.
Cannot have received: tumor resection
Recent (within 1 month) tumor resection or radio-chemotherapy
Cannot have received: radio-chemotherapy
Recent (within 1 month) tumor resection or radio-chemotherapy
Lab requirements
Blood counts
CBC within 14 days.
Kidney function
Multiphasic (including BUN, creatinine) within 14 days.
Liver function
Multiphasic (including total bilirubin, AST and ALT) within 14 days.
Physical exam within 28 days of PET imaging, CBC and Multiphasic (including electrolytes, BUN, creatinine, total bilirubin, AST and ALT) within 14 days.
Structured fields extracted by AI. May contain errors — verify against the official protocol.
US trial sites
- Karmanos Cancer Institute · Detroit, Michigan
Showing up to 5 US sites. See all sites on ClinicalTrials.gov →
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