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OncoMatch/Clinical Trials/NCT05489211

Study of Dato-DXd as Monotherapy and in Combination With Anti-cancer Agents in Patients With Advanced Solid Tumours (TROPION-PanTumor03)

Is NCT05489211 recruiting? Yes, currently enrolling (May 2026). This Phase 2 trial studies multiple treatments for endometrial cancer.

Phase 2RecruitingAstraZenecaNCT05489211Data as of May 2026

Treatment: Datopotamab deruxtecan (Dato-DXd) · Capecitabine · 5-Fluorouracil · Volrustomig · Carboplatin · Bevacizumab · Rilvegostomig · Prednisone/ prednisolone · CisplatinTROPION-PanTumor03 will investigate the safety, tolerability, and anti-tumour activity of Datopotamab Deruxtecan (Dato-DXd) as Monotherapy and in Combination with Anticancer Agents in Patients with Advanced/Metastatic Solid Tumours.

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Extracted eligibility criteria

Cancer type

Endometrial Cancer

Gastric Cancer

Prostate Cancer

Ovarian Cancer

Colorectal Cancer

Urothelial Carcinoma

Cholangiocarcinoma

Disease stage

Metastatic disease required

Documented advanced or metastatic malignancy

Performance status

ECOG 0–1(Restricted strenuous activity)

Prior therapy

Cannot have received: TROP2-directed therapy

Prior treatment with TROP2-directed therapies

Cannot have received: antibody-drug conjugate

Exception: with deruxtecan payload

Prior treatment with ... other antibody-drug conjugate (ADCs) with deruxtecan payload

Lab requirements

Blood counts

Adequate bone marrow reserve and organ function

Kidney function

Adequate bone marrow reserve and organ function

Liver function

Adequate bone marrow reserve and organ function

Adequate bone marrow reserve and organ function

Structured fields extracted by AI. May contain errors — verify against the official protocol.

US trial sites

  • Research Site · Los Angeles, California
  • Research Site · San Diego, California
  • Research Site · Santa Rosa, California
  • Research Site · Muncie, Indiana
  • Research Site · Kansas City, Kansas

Showing up to 5 US sites. See all sites on ClinicalTrials.gov →

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