OncoMatch

OncoMatch/Clinical Trials/NCT05473910

A Study of TSC-100 and TSC-101 in AML, ALL and MDS in Patients Undergoing Allogeneic Peripheral Blood Stem Transplantation

Is NCT05473910 recruiting? Yes, currently enrolling (May 2026). This Phase 1 trial studies multiple treatments including SOC + TSC-100 and SOC + TSC-101 for aml.

Phase 1RecruitingTScan Therapeutics, Inc.NCT05473910Data as of May 2026

Treatment: SOC + TSC-100 · SOC + TSC-101 — This is a multi-center, non-randomized, concurrent controlled, multi-arm, Phase 1 interventional, open-label, biologic assignment-based umbrella study evaluating the feasibility, safety and preliminary efficacy of an escalating dose regimen of up to 2 doses of TSC-100 and TSC-101 in patients with AML, MDS, or ALL following HCT from a haploidentical donor, MMUD, or MUD

Check if I qualify

Extracted eligibility criteria

Cancer type

Acute Myeloid Leukemia

Myelodysplastic Syndrome

Acute Lymphoblastic Leukemia

Biomarker criteria

Required: HLA-A A*0201 expression

Participants in the treatment arms must express HLA-A*0201. Participants in the control arm may express any HLA type.

Required: HMHA1 HA-1 positive genotype (HA1+/- or HA-1+/+)

Having the HA1+/- or HA-1+/+ (HA-1 positive) genotype to be eligible for TSC-100 treatment.

Required: HMHA2 HA-2 positive genotype (HA2+/- or HA-2+/+)

Having the HA2+/- HA-2+/+ (HA-2 positive) genotype to be eligible for TSC-101 treatment.

Excluded: HLA-A A*02:07 positive

Participants who meet inclusion criteria for TSC-101 but who are also positive for HLAA*02:07.

Performance status

ECOG 0–2(Ambulatory, capable of self-care)

Prior therapy

Cannot have received: allogeneic hematopoietic cell transplantation

Prior allogeneic HCT.

Structured fields extracted by AI. May contain errors — verify against the official protocol.

US trial sites

  • City of Hope · Duarte, California
  • Yale · New Haven, Connecticut
  • Memorial Healthcare System · Hollywood, Florida
  • Northside Hospital · Atlanta, Georgia
  • John Hopkins University · Baltimore, Maryland

Showing up to 5 US sites. See all sites on ClinicalTrials.gov →

Could you qualify for this trial?

Enter your biomarker results to see how this trial's eligibility criteria match your specific cancer profile.

Check if I qualify