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OncoMatch/Clinical Trials/NCT05463263

A Phase 1/2 Study of STP938 for Adult Subjects With Relapsed/Refractory B-Cell and T-Cell Lymphomas

Is NCT05463263 recruiting? Yes, currently enrolling (May 2026). This Phase 1/2 trial studies STP938 for lymphoma, b-cell.

Phase 1/2RecruitingStep Pharma, SASNCT05463263Data as of May 2026

Treatment: STP938The Phase 1 part of the study is a dose escalation of STP938 as monotherapy. The Phase 2 part of the study is cohort expansion of STP938 as a monotherapy in 5 different B and T cell lymphomas.

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Extracted eligibility criteria

Cancer type

Non-Hodgkin Lymphoma

Performance status

ECOG 0–2(Ambulatory, capable of self-care)

Prior therapy

Min 2 prior lines

Cannot have received: radiation therapy

Exception: must have measurable disease outside of the radiation field

Prior radiation or surgical resection of their lymphoma without additional sites of measurable disease outside of the radiation field

Cannot have received: radiation therapy

Exception: must be >2 weeks prior to first dose

subjects who have received prior radiation or surgical resection of their lymphoma ≤2 weeks prior to the first dose of study drug

Cannot have received: systemic cancer treatments

Exception: must be >4 weeks before enrollment or >5 half-lives since completion of previous investigational therapy, whichever is shorter

Systemic cancer treatments, monoclonal antibody-directed therapies, other investigational agents within 4 weeks before enrollment, or <5 half-lives since completion of previous investigational therapy, whichever is shorter.

Lab requirements

Blood counts

adequate bone marrow function and coagulation

Kidney function

adequate renal function

Liver function

adequate hepatic function

Cardiac function

QTcF ≤470 msec based on averaged triplicate ECG readings at Screening Visit

Adequate organ function (bone marrow, hepatic, renal function and coagulation). Subjects with corrected QT interval >470 msec based on averaged triplicate electrocardiogram (ECG) readings at the Screening Visit using the QT interval corrected for heart rate using Fridericia's method (QTcF).

Structured fields extracted by AI. May contain errors — verify against the official protocol.

US trial sites

  • Colorado Blood Cancer Institute · Denver, Colorado
  • Florida Cancer Specialists · Sarasota, Florida
  • Memorial Sloan Kettering · New York, New York

Showing up to 5 US sites. See all sites on ClinicalTrials.gov →

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