OncoMatch

OncoMatch/Clinical Trials/NCT05454488

An Evidence-Based Focal Cryotherapy Protocol for Focal Ablation of Intermediate Risk Prostate Cancer

Is NCT05454488 recruiting? Yes, currently enrolling (May 2026). This Phase 2 trial studies Focal Cryoablation for prostate cancer.

Phase 2RecruitingM.D. Anderson Cancer CenterNCT05454488Data as of May 2026

Treatment: Focal CryoablationTo learn if using cryotherapy to treat only the part of the prostate known to contain cancer is effective in controlling prostate cancer

Check if I qualify

Extracted eligibility criteria

Cancer type

Prostate Cancer

Disease stage

Required: Stage ≤T2BN0M0

Grade: gg2gg3 (gleason grade group)

Prior therapy

No prior treatment (treatment-naive required)
Max 0 prior lines

Cannot have received: radiation therapy

Any previous treatment for prostate cancer, including radiation therapy

Cannot have received: hormonal treatment

Any previous treatment for prostate cancer, including ... hormonal treatment

Cannot have received: biologic therapy

Any previous treatment for prostate cancer, including ... biologic therapy for prostate cancer

Cannot have received: chemotherapy

Any previous treatment for prostate cancer, including ... chemotherapy

Cannot have received: prostate outlet procedure (TURP, HoLEP, greenlight, microwave ablation, aquablation, UroLift, simple prostatectomy)

Prior TURP or other prostate outlet procedure such as HoLEP, greenlight, microwave ablation, aquablation, UroLift, or simple prostatectomy

Structured fields extracted by AI. May contain errors — verify against the official protocol.

US trial sites

  • MD Anderson Cancer Center · Houston, Texas

Showing up to 5 US sites. See all sites on ClinicalTrials.gov →

Could you qualify for this trial?

Enter your biomarker results to see how this trial's eligibility criteria match your specific cancer profile.

Check if I qualify