OncoMatch/Clinical Trials/NCT05451004
SPECT-CT Guided ELEctive Contralateral Neck Treatment for Patients With Lateralized Oropharyngeal Cancer
Is NCT05451004 recruiting? Yes, currently enrolling (Jun 2026). This Phase 3 trial studies non-drug interventions for oropharyngeal cancer.
This study is being done to answer the following question: Is the chance of cancer spreading or returning the same if radiotherapy to the neck is guided, by using a special imaging study called lymph node mapping (lymphatic mapping) Single Photon Emission Computed Tomography (SPECT-CT), compared to the usual treatment when radiotherapy is given to both sides of the neck?
Check if I qualifyExtracted eligibility criteria
Cancer type
Head and Neck Squamous Cell Carcinoma
Biomarker criteria
Allowed: HPV positive
HPV positive or negative (by p16 immunohistochemistry)
Allowed: HPV negative
HPV positive or negative (by p16 immunohistochemistry)
Performance status
ECOG 0–2(Ambulatory, capable of self-care)
Prior therapy
Cannot have received: induction or neo-adjuvant chemotherapy
Previous induction or neo-adjuvant chemotherapy
Cannot have received: radiation therapy to the head and neck
Previous radiation therapy to the head and neck
Cannot have received: comprehensive neck dissection of at least 3 levels on either side
Exception: Patients who have had excisional biopsies of involved lymph nodes are eligible
comprehensive neck dissection of at least 3 levels on either side
Structured fields extracted by AI. May contain errors — verify against the official protocol.
US trial sites
- City of Hope Corona · Corona, California
- City of Hope Comprehensive Cancer Center · Duarte, California
- UM Sylvester Comprehensive Cancer Center at Coral Gables · Coral Gables, Florida
- Baptist MD Anderson Cancer Center · Jacksonville, Florida
- University of Miami Miller School of Medicine-Sylvester Cancer Center · Miami, Florida
Showing up to 5 US sites.
See all sites on ClinicalTrials.gov →Frequently asked questions
Is NCT05451004 currently recruiting?
Yes, this trial is currently recruiting patients.
Are there prior therapy exclusions?
Yes. Prior induction or neo-adjuvant chemotherapy, radiation therapy to the head and neck, comprehensive neck dissection of at least 3 levels on either side disqualifies patients from enrollment.
Could you qualify for this trial?
Enter your biomarker results to see how this trial's eligibility criteria match your specific cancer profile.
Check if I qualifyRelated pages