OncoMatch/Clinical Trials/NCT05451004
SPECT-CT Guided ELEctive Contralateral Neck Treatment for Patients With Lateralized Oropharyngeal Cancer
Is NCT05451004 recruiting? Yes, currently enrolling (May 2026). This Phase 3 trial studies non-drug interventions for oropharyngeal cancer.
This study is being done to answer the following question: Is the chance of cancer spreading or returning the same if radiotherapy to the neck is guided, by using a special imaging study called lymph node mapping (lymphatic mapping) Single Photon Emission Computed Tomography (SPECT-CT), compared to the usual treatment when radiotherapy is given to both sides of the neck?
Check if I qualifyExtracted eligibility criteria
Cancer type
Head and Neck Squamous Cell Carcinoma
Biomarker criteria
Allowed: HPV positive
HPV positive or negative (by p16 immunohistochemistry)
Allowed: HPV negative
HPV positive or negative (by p16 immunohistochemistry)
Performance status
ECOG 0–2(Ambulatory, capable of self-care)
Prior therapy
Cannot have received: induction or neo-adjuvant chemotherapy
Previous induction or neo-adjuvant chemotherapy
Cannot have received: radiation therapy to the head and neck
Previous radiation therapy to the head and neck
Cannot have received: comprehensive neck dissection of at least 3 levels on either side
Exception: Patients who have had excisional biopsies of involved lymph nodes are eligible
comprehensive neck dissection of at least 3 levels on either side
Structured fields extracted by AI. May contain errors — verify against the official protocol.
US trial sites
- City of Hope Corona · Corona, California
- City of Hope Comprehensive Cancer Center · Duarte, California
- UM Sylvester Comprehensive Cancer Center at Coral Gables · Coral Gables, Florida
- Baptist MD Anderson Cancer Center · Jacksonville, Florida
- University of Miami Miller School of Medicine-Sylvester Cancer Center · Miami, Florida
Showing up to 5 US sites. See all sites on ClinicalTrials.gov →
Could you qualify for this trial?
Enter your biomarker results to see how this trial's eligibility criteria match your specific cancer profile.
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