OncoMatch/Clinical Trials/NCT05423210
Atezolizumab and Pre-Surgical Brain Radiation Therapy for Glioblastoma Multiforme
Is NCT05423210 recruiting? Yes, currently enrolling (May 2026). This Early Phase 1 trial studies Atezolizumab + FSRT radiation for glioblastoma multiforme.
Treatment: Atezolizumab + FSRT radiation — This is a single-arm pilot study that will recruit 12 patients with newly diagnosed Glioblastoma, a malignant brain tumor with a poor prognosis. Patients will be treated with fractionated stereotactic radiotherapy (FSRT) for 2 weeks, in addition to two doses of Atezolizumab (Tecentriq), an FDA approved PD- L1 inhibitor drug, 840 mg IV, at the beginning and at the end of the two-week time period, concomitantly with FSRT. After this initial two weeks treatment the patients will undergo craniotomy and maximal safe resection as per normal care for a GB. After surgery patients will follow the normal care for glioblastoma in addition to Atezolizumab 840 mg IV q2 weeks for the duration of adjuvant treatment.
Check if I qualifyExtracted eligibility criteria
Cancer type
Glioblastoma
Disease stage
Required: Stage IV (WHO)
Grade: IV (WHO)
glioblastoma multiforme WHO Grade IV
Performance status
ECOG 0–2(Ambulatory, capable of self-care)
Prior therapy
Cannot have received: surgery
Patient already underwent surgical total or partial tumor resection
Cannot have received: radiation therapy
Patient already underwent...radiation therapy
Cannot have received: CD137 agonist
Prior treatment with CD137 agonists
Cannot have received: immune checkpoint inhibitor
Prior treatment with...immune checkpoint blockade therapies
Cannot have received: systemic immunostimulatory agent
Treatment with systemic immunostimulatory agents
Cannot have received: systemic immunosuppressive medication
Treatment with systemic immunosuppressive medication
Lab requirements
Blood counts
Kidney function
Liver function
Adequate organ function
Structured fields extracted by AI. May contain errors — verify against the official protocol.
US trial sites
- Stony Brook University Hospital · Stony Brook, New York
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