OncoMatch/Clinical Trials/NCT05419518
Palliative Dose Escalated Radiation for Painful Non-Spine Bone Metastases and Painful Non-Bone Metas
Is NCT05419518 recruiting? Yes, currently enrolling (May 2026). This Phase 2 trial studies EXTERNAL BEAM RADIATION for neoplasm metastases.
Treatment: EXTERNAL BEAM RADIATION — The investigators hypothesize that with dose escalation to 40-50 Gy in ten fractions, the complete pain response rate at one month can be increased to 40-50% in painful non-spinal bone metastases. Additionally, the investigators hypothesize that utilizing a fractionation scheme with an escalated biologically equivalent dose (BED) will result in a higher proportion of participants responding to treatment, and will also lead to more durable responses. Furthermore, the investigators hypothesize that with dose escalation to 40-50 Gy in ten fractions, the complete pain response rate at one month can be increased to 35-45% in painful non-bone metastases
Check if I qualifyExtracted eligibility criteria
Disease stage
Metastatic disease required
Prior therapy
Cannot have received: radiation therapy
Structured fields extracted by AI. May contain errors — verify against the official protocol.
US trial sites
- RWJBarnabas Health - Robert Wood Johnson University Hospital · Hamilton, New Jersey
- RWJBarnabas Health - Monmouth Medical Center Southern Campus · Lakewood, New Jersey
- RWJBarnabas Health - Saint Barnabas Medical Center · Livingston, New Jersey
- Robert Wood Johnson University Hospital · New Brunswick, New Jersey
- Cancer Institute of New Jersey · New Brunswick, New Jersey
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