OncoMatch/Clinical Trials/NCT05414500
Mogamulizumab and Brentuximab Vedotin in CTCL and Mycosis Fungoides
Is NCT05414500 recruiting? Yes, currently enrolling (May 2026). This Phase 1 trial studies multiple treatments including Mogamulizumab and Brentuximab vedotin for cutaneous t cell lymphoma.
Treatment: Mogamulizumab · Brentuximab vedotin — This is an open label, single center, non-randomized dose de-escalation phase I study of combination of BV and Mogamulizumab. The primary objective of the study is to assess the safety and tolerability of the combination. The primary objective is also to explore safe dose of combination for future expansion.
Check if I qualifyExtracted eligibility criteria
Cancer type
Non-Hodgkin Lymphoma
Biomarker criteria
Required: CD30 positivity (>1%)
Disease stage
Required: Stage II, III, IV
Performance status
ECOG 0–2(Ambulatory, capable of self-care)
Prior therapy
Must have received: systemic therapy (bexarotene, interferons, extracorporeal photopheresis, methotrexate, gemcitabine, vorinostat)
Must have received at least one prior systemic therapy like bexarotene, interferons, ECP, methotrexate, Gemcitabine, Vorinostat etc. (patients who have received only skin directed therapy are not allowed)
Cannot have received: Brentuximab vedotin (Brentuximab vedotin)
Exception: Prior exposure of BV is allowed if it is >6 months ago and CD30+ in >1% of in biopsy after last BV
Prior exposure of BV < 6 months ago, or Moga. Prior exposure of BV is allowed if it is >6 months ago and CD30+ in >1% of in biopsy after last BV
Cannot have received: mogamulizumab (mogamulizumab)
Prior exposure of BV < 6 months ago, or Moga.
Lab requirements
Kidney function
estimated gfr >40 ml/min/1.73 m2
Liver function
t bili <2 x uln, isolated bilirubin of >2 is accepted if there is suspected diagnosis of gilbert's syndrome, ast and alt <3x uln
Cardiac function
lvef >40%
Structured fields extracted by AI. May contain errors — verify against the official protocol.
US trial sites
- University of Alabama at Birmingham · Birmingham, Alabama
Showing up to 5 US sites. See all sites on ClinicalTrials.gov →
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