OncoMatch

OncoMatch/Clinical Trials/NCT05377996

A Study of Emiltatug Ledadotin (Emi-Le) in Participants With Solid Tumors

Is NCT05377996 recruiting? Yes, currently enrolling (Sep 2026). This Phase 1/2 trial studies Emi-Le for triple negative breast cancer.

Phase 1/2RecruitingDay One Biopharmaceuticals, Inc.NCT05377996Data as of Sep 2026

Treatment: Emi-LeA Study of Emi-Le in Participants with Solid Tumors

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Extracted eligibility criteria

Treatments studied

Other

Emi-Le

Cancer type

Triple-Negative Breast Cancer

Breast Carcinoma

Endometrial Cancer

Ovarian Cancer

Head and Neck Squamous Cell Carcinoma

Performance status

ECOG 0–1(Restricted strenuous activity)

Eastern Cooperative Oncology Group (ECOG) performance status 0 or 1

Prior therapy

Cannot have received: antibody-drug conjugate with auristatin payload

Prior treatment with an Antibody Drug Conjugate (ADC) containing an auristatin payload. Prior treatment with another ADC containing other payloads is allowed.

Cannot have received: B7-H4 targeted treatment

Prior B7-H4 targeted treatment

Lab requirements

Cardiac function

Clinically significant cardiovascular disease

Clinically significant cardiovascular disease

Structured fields extracted by AI. May contain errors — verify against the official protocol.

US trial sites

  • Mayo Clinic Comprehensive Cancer Center · Phoenix, Arizona
  • UC Irvine Health-Chao Family Comprehensive Cancer Center · Orange, California
  • UCSF Helen Diller Family Comprehensive Cancer Center · San Francisco, California
  • UCLA David Geffen School of Medicine, Division of Hematology/Oncology · Santa Monica, California
  • Mayo Clinic - Jacksonville · Jacksonville, Florida

Showing up to 5 US sites.

See all sites on ClinicalTrials.gov →

Frequently asked questions

Is NCT05377996 currently recruiting?

Yes, this trial is currently recruiting patients.

Are there prior therapy exclusions?

Yes. Prior antibody-drug conjugate with auristatin payload, B7-H4 targeted treatment disqualifies patients from enrollment.

Could you qualify for this trial?

Enter your biomarker results to see how this trial's eligibility criteria match your specific cancer profile.

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