OncoMatch/Clinical Trials/NCT05370430
BAFFR-targeting CAR T Cells for Patients With Relapsed or Refractory B-NHL
Is NCT05370430 recruiting? Yes, currently enrolling (Jun 2026). This Phase 1 trial studies BAFFR-CAR T cells for relapsed or refractory b-cell non-hodgkin's lymphoma.
Treatment: BAFFR-CAR T cells — A Phase 1 Study Evaluating BAFFR-targeting CAR T Cells for Patients with Relapsed or Refractory B-cell Non-Hodgkin's Lymphoma (B-NHL)
Check if I qualifyExtracted eligibility criteria
Treatments studied
Other
Cancer type
Non-Hodgkin Lymphoma
Biomarker criteria
Required: TNFRSF13C overexpression
BAFF-R expression on lymphoma cells required
Performance status
ECOG 0–2(Ambulatory, capable of self-care)
Prior therapy
Cannot have received: allogeneic stem cell transplant
Prior allogeneic SCT
Cannot have received: autologous stem cell transplant
Exception: allowed if ≥ 6 months before leukapheresis
Autologous SCT < 6 months before leukapheresis
Lab requirements
Blood counts
anc ≥ 1000/μl, platelets ≥ 75,000/μl (exceptions for bm involvement)
Kidney function
crcl ≥ 50 ml/min
Liver function
bilirubin ≤ 1.5x uln (except gilbert's), ast/alt < 3x uln
Cardiac function
lvef ≥ 45%, qtcf ≤ 480 ms, o₂ saturation > 91% on room air
Structured fields extracted by AI. May contain errors — verify against the official protocol.
US trial sites
- City of Hope Medical Center · Duarte, California
- Stanford University · Stanford, California
- University of Kansas Hospital · Kansas City, Kansas
- University of Minnesota · Minneapolis, Minnesota
- Atrium Health Levine Cancer Institute - Morehead · Charlotte, North Carolina
Showing up to 5 US sites.
See all sites on ClinicalTrials.gov →Frequently asked questions
Is NCT05370430 currently recruiting?
Yes, this trial is currently recruiting patients.
Are there prior therapy exclusions?
Yes. Prior allogeneic stem cell transplant, autologous stem cell transplant disqualifies patients from enrollment.
Does this trial require TNFRSF13C?
Yes, TNFRSF13C overexpression is a required biomarker for enrollment.
Could you qualify for this trial?
Enter your biomarker results to see how this trial's eligibility criteria match your specific cancer profile.
Check if I qualifyRelated pages