OncoMatch/Clinical Trials/NCT05366179
Autologous CAR-T Cells Targeting B7-H3 in Recurrent or Refractory GBM CAR.B7-H3Tc
Is NCT05366179 recruiting? Yes, currently enrolling (May 2026). This Phase 1 trial studies CAR.B7-H3T cells infusion for glioblastoma multiforme.
Treatment: CAR.B7-H3T cells infusion — The purpose of this study is to test the safety of using T lymphocyte chimeric antigen receptor cells against the B7-H3 antigen (CAR.B7-H3T cells) in patients with glioblastoma. CAR.B7-H3T cells treatment has not been tested in humans and is not an approved treatment by the Food and Drug Administration for glioblastoma.
Check if I qualifyExtracted eligibility criteria
Cancer type
Glioblastoma
Prior therapy
Must have received: radiation therapy
Must have undergone at least 4005 cGy of radiation with concurrent temozolomide.
Must have received: cytotoxic chemotherapy (temozolomide) — concurrent with radiation
Must have undergone at least 4005 cGy of radiation with concurrent temozolomide.
Must have received: — surgery or biopsy at initial diagnosis
Must have previously undergone resection or biopsy at initial diagnosis.
Cannot have received: antiangiogenic agent (bevacizumab)
No current or previous exposure to antiangiogenic agents, such as bevacizumab.
Cannot have received: chimeric antigen receptor T cell therapy
Prior exposure to chimeric antigen receptor T cell therapy for treatment of glioblastoma.
Cannot have received: (carmustine wafers)
Previously implanted carmustine wafers or brachytherapy for the treatment of glioma.
Cannot have received: brachytherapy
Previously implanted carmustine wafers or brachytherapy for the treatment of glioma.
Structured fields extracted by AI. May contain errors — verify against the official protocol.
US trial sites
- Lineberger Comprehensive Cancer Center · Chapel Hill, North Carolina
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