OncoMatch/Clinical Trials/NCT05351788
SKB264 Combinatiton Therapy in Patients With Advanced or Metastatic Non-small Cell Lung Cancer.
Is NCT05351788 recruiting? Yes, currently enrolling (May 2026). This Phase 2 trial studies multiple treatments including SKB264 and KL-A167 for non-small cell lung cancer.
Treatment: SKB264 · KL-A167 · Carboplatin · Cisplatin — The purpose of this study is to assess the safety, tolerability and preliminary antitumor activity of SKB264 in combination with KL-A167 with or without chemotherapy with advanced or metastatic non-small cell lung cancer. The study is divided into two parts. Part 1 will be the safety run-in phase, and Part 2 will be the cohort expansion phase.
Check if I qualifyExtracted eligibility criteria
Cancer type
Non-Small Cell Lung Carcinoma
Biomarker criteria
Required: ALK wild-type
Required: ALK wild-type
Required: EGFR activating mutation
Required: EGFR wild-type
Disease stage
Metastatic disease required
Patients with locally advanced/metastatic NSCLC; at least one measurable lesion per RECIST v1.1 criteria
Performance status
ECOG 0–1(Restricted strenuous activity)
Prior therapy
Must have received: EGFR tyrosine kinase inhibitor — advanced or metastatic
who have failed previous treatment with EGFR-TKIs
Lab requirements
Blood counts
adequate organ and bone marrow function
Kidney function
adequate organ and bone marrow function
Liver function
adequate organ and bone marrow function
Adequate organ and bone marrow function
Structured fields extracted by AI. May contain errors — verify against the official protocol.
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