OncoMatch/Clinical Trials/NCT05333302
Pilot CAR-T Cells Therapy for Children/Young Adults With CD19+ R/R Leukemia/Lymphoma
Is NCT05333302 recruiting? Yes, currently enrolling (Jun 2026). This Phase 1 trial studies multiple treatments including CD19 CAR-T-cells and Tocilizumab for b-cell acute lymphoblastic leukemia.
Treatment: CD19 CAR-T-cells · Tocilizumab — The purpose of this study is to estimate the safety and the efficacy of CAR- T cells immunotherapy for children/young adults with relapsed or refractory acute lymphoblastic leukemia/lymphoma.
Check if I qualifyExtracted eligibility criteria
Treatments studied
Other
Cancer type
Acute Lymphoblastic Leukemia
Non-Hodgkin Lymphoma
Biomarker criteria
Required: CD19 overexpression (positive)
CD19+ relapsed or refractory lymphoblastic leukemia/lymphoma
Demographics
Prior therapy
Cannot have received: donor lymphocyte transfusion
Exception: allowed if >6 weeks before CAR-T cells infusion
transfusion of donor lymphocyte less than 6 week before CAR-T cells infusion
Lab requirements
Blood counts
T-cells count in peripheral blood >150 cells/µL
Kidney function
serum creatinine level >=3x upper limit of normal for age excluded
Liver function
ALT or AST >=3x upper limit of normal for age excluded
T-cells count in peripheral blood >150 cells/µL; severe hepatic dysfunction: ALT or AST >=3x upper limit of normal for age; renal dysfunction: serum creatinine level >=3x upper limit of normal for age
Structured fields extracted by AI. May contain errors — verify against the official protocol.
Frequently asked questions
Is NCT05333302 currently recruiting?
Yes, this trial is currently recruiting patients.
Are there prior therapy exclusions?
Yes. Prior donor lymphocyte transfusion disqualifies patients from enrollment.
Does this trial require CD19?
Yes, CD19 overexpression is a required biomarker for enrollment.
Is there an age limit?
Yes. Patients must be 30 years or younger and at least 1 years old.
Could you qualify for this trial?
Enter your biomarker results to see how this trial's eligibility criteria match your specific cancer profile.
Check if I qualify