OncoMatch/Clinical Trials/NCT05320198
Study of DISC-0974 (RALLY-MF) in Participants With Myelofibrosis or Myelodysplastic Syndrome and Anemia
Is NCT05320198 recruiting? Yes, currently enrolling (May 2026). This Phase 1/2 trial studies DISC-0974 for myelofibrosis; anemia.
Treatment: DISC-0974 — This phase 1b/2a open-label study will assess the safety, tolerability, pharmacokinetics and pharmacodynamics of DISC-0974 as well as categorize the effects on anemia response in subjects with myelofibrosis or myelodysplastic syndrome and anemia.
Check if I qualifyExtracted eligibility criteria
Cancer type
Myeloproliferative Neoplasm
Myelodysplastic Syndrome
Performance status
ECOG 0–2(Ambulatory, capable of self-care)
Prior therapy
Cannot have received: iron chelation therapy
Iron chelation therapy in the 28 days prior to Screening
Cannot have received: hypomethylating agent or other acute myeloid leukemia (AML)-like combination chemotherapy
Prior treatment with hypomethylating agent or other acute myeloid leukemia (AML)-like combination chemotherapy
Lab requirements
Blood counts
Platelet count ≥25,000/μL and <1,000,000/μL; neutrophils ≥1,000/μL; total WBC count <50,000/μL at Screening
Kidney function
eGFR ≥30 mL/min/1.73 m2 by the CKD-EPI formula
Liver function
AST and ALT <3x ULN at Screening; Direct bilirubin <2x ULN at Screening. Higher levels are acceptable if attributed to ineffective erythropoiesis or Gilbert's syndrome (with approval from Sponsor).
Platelet count ≥25,000/μL and <1,000,000/μL; neutrophils ≥1,000/μL; total WBC count <50,000/μL at Screening. eGFR ≥30 mL/min/1.73 m2 by the CKD-EPI formula. AST and ALT <3x ULN at Screening. Direct bilirubin <2x ULN at Screening.
Structured fields extracted by AI. May contain errors — verify against the official protocol.
US trial sites
- City of Hope - Duarte · Duarte, California
- City of Hope - Lennar · Irvine, California
- University of Colorado Anschutz Medical Campus · Aurora, Colorado
- Mayo Clinic Jacksonville · Jacksonville, Florida
- Sylvester Cancer Center - U Miami · Miami, Florida
Showing up to 5 US sites. See all sites on ClinicalTrials.gov →
Could you qualify for this trial?
Enter your biomarker results to see how this trial's eligibility criteria match your specific cancer profile.
Check if I qualify