OncoMatch/Clinical Trials/NCT05320198
Study of DISC-0974 (RALLY-MF) in Participants With Myelofibrosis or Myelodysplastic Syndrome and Anemia
Is NCT05320198 recruiting? Yes, currently enrolling (Jun 2026). This Phase 1/2 trial studies DISC-0974 for myelofibrosis; anemia.
Treatment: DISC-0974 — This phase 1b/2a open-label study will assess the safety, tolerability, pharmacokinetics and pharmacodynamics of DISC-0974 as well as categorize the effects on anemia response in subjects with myelofibrosis or myelodysplastic syndrome and anemia.
Check if I qualifyExtracted eligibility criteria
Treatments studied
Other
Cancer type
Myeloproliferative Neoplasm
Myelodysplastic Syndrome
Performance status
ECOG 0–2(Ambulatory, capable of self-care)
Prior therapy
Cannot have received: iron chelation therapy
Iron chelation therapy in the 28 days prior to Screening
Cannot have received: hypomethylating agent or other acute myeloid leukemia (AML)-like combination chemotherapy
Prior treatment with hypomethylating agent or other acute myeloid leukemia (AML)-like combination chemotherapy
Lab requirements
Blood counts
Platelet count ≥25,000/μL and <1,000,000/μL; neutrophils ≥1,000/μL; total WBC count <50,000/μL at Screening
Kidney function
eGFR ≥30 mL/min/1.73 m2 by the CKD-EPI formula
Liver function
AST and ALT <3x ULN at Screening; Direct bilirubin <2x ULN at Screening. Higher levels are acceptable if attributed to ineffective erythropoiesis or Gilbert's syndrome (with approval from Sponsor).
Platelet count ≥25,000/μL and <1,000,000/μL; neutrophils ≥1,000/μL; total WBC count <50,000/μL at Screening. eGFR ≥30 mL/min/1.73 m2 by the CKD-EPI formula. AST and ALT <3x ULN at Screening. Direct bilirubin <2x ULN at Screening.
Structured fields extracted by AI. May contain errors — verify against the official protocol.
US trial sites
- City of Hope - Duarte · Duarte, California
- City of Hope - Lennar · Irvine, California
- University of Colorado Anschutz Medical Campus · Aurora, Colorado
- Mayo Clinic Jacksonville · Jacksonville, Florida
- Sylvester Cancer Center - U Miami · Miami, Florida
Showing up to 5 US sites.
See all sites on ClinicalTrials.gov →Frequently asked questions
Is NCT05320198 currently recruiting?
Yes, this trial is currently recruiting patients.
Are there prior therapy exclusions?
Yes. Prior iron chelation therapy, hypomethylating agent or other acute myeloid leukemia (AML)-like combination chemotherapy disqualifies patients from enrollment.
Could you qualify for this trial?
Enter your biomarker results to see how this trial's eligibility criteria match your specific cancer profile.
Check if I qualify