OncoMatch/Clinical Trials/NCT05317403
Venetoclax to Augment Epigenetic Modification and Chemotherapy
Official title: A Phase I Study of Venetoclax to Augment Epigenetic Modification and Chemotherapy in Pediatric and Young Adult Patients With Relapsed and Refractory Acute Myeloid Leukemia
Is NCT05317403 recruiting? Yes, currently enrolling (Oct 2026). This Phase 1 trial studies multiple treatments for acute myeloid leukemia, in relapse.
Treatment: Venetoclax · Azacitadine · Vorinostat · Cytarabine · Fludarabine · Filgrastim — The investigator is testing the addition of venetoclax to 5-azacitidine and vorinostat followed by standard chemotherapy to enhance treatment response in AML patients.
Check if I qualifyExtracted eligibility criteria
Treatments studied
Targeted therapy
Chemotherapy
Other
Cancer type
Acute Myeloid Leukemia
Demographics
Lab requirements
Kidney function
Calculated creatinine clearance or radioisotope GFR ≥ 70ml/min/1.73m2 OR a normal serum creatinine
Liver function
Direct bilirubin < 1.5 x ULN for age or normal, AND ALT < 5 x ULN for age. Hepatic requirements are waived for patients with known or suspected liver involvement by leukemia, with study chair approval.
Cardiac function
Shortening fraction of ≥ 27% OR ejection fraction of ≥ 50%
Adequate renal and hepatic functions as indicated by the following laboratory values: ... Adequate Cardiac Function Defined as: Shortening fraction of ≥ 27% OR ejection fraction of ≥ 50%.
Structured fields extracted by AI. May contain errors — verify against the official protocol.
US trial sites
- Children's Wisconsin · Milwaukee, Wisconsin
Showing up to 5 US sites.
See all sites on ClinicalTrials.gov →Frequently asked questions
Is NCT05317403 currently recruiting?
Yes, this trial is currently recruiting patients.
Is there an age limit?
Yes. Patients must be 25 years or younger and at least 1 years old.
Could you qualify for this trial?
Enter your biomarker results to see how this trial's eligibility criteria match your specific cancer profile.
Check if I qualifyRelated pages