OncoMatch/Clinical Trials/NCT05315700
Study of ORIC-114 in Patients With Advanced Solid Tumors Harboring an EGFR or HER2 Alteration
Is NCT05315700 recruiting? Yes, currently enrolling (May 2026). This Phase 1/2 trial studies multiple treatments including ORIC-114 and Chemotherapy drug for solid tumors.
Treatment: ORIC-114 · Chemotherapy drug — The purpose of this study is to establish the recommended Phase 2 dose (RP2D) and/or maximum tolerated dose (MTD), safety, pharmacokinetics (PK), pharmacodynamics (PD), and antitumor activity of ORIC-114 as a Single Agent or in Combination with Chemotherapy when administered to patients with advanced solid tumors harboring an EGFR or HER2 alteration.
Check if I qualifyExtracted eligibility criteria
Cancer type
Tumor Agnostic
Biomarker criteria
Required: EGFR exon 20 insertion mutation
EGFR exon 20 insertion mutation
Required: EGFR atypical mutation
atypical EGFR mutation
Required: HER2 (ERBB2) exon 20 insertion mutation
HER2 exon 20 insertion mutation
Required: HER2 (ERBB2) amplification
HER2 amplification as determined by an in situ hybridization (ISH) test
Required: HER2 (ERBB2) overexpression
HER2 overexpression as determined by an immunohistochemistry (IHC) test
Excluded: EGFR T790M
Known EGFR T790M mutation
Performance status
ECOG 0–1(Restricted strenuous activity)
Lab requirements
Blood counts
Kidney function
Liver function
Cardiac function
No history of class III or IV congestive heart failure or severe non-ischemic cardiomyopathy, unstable or poorly controlled angina, myocardial infarction, or ventricular arrhythmia within the previous 6 months
Adequate organ function; History of class III or IV congestive heart failure or severe non-ischemic cardiomyopathy, unstable or poorly controlled angina, myocardial infarction, or ventricular arrhythmia within the previous 6 months [excluded]
Structured fields extracted by AI. May contain errors — verify against the official protocol.
US trial sites
- City of Hope · Duarte, California
- City of Hope · Huntington Beach, California
- City of Hope · Irvine, California
- City of Hope · Long Beach, California
- University of California, San Francisco · San Francisco, California
Showing up to 5 US sites. See all sites on ClinicalTrials.gov →
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