OncoMatch/Clinical Trials/NCT05289687
Daratumumab for Chemotherapy-Refractory Minimal Residual Disease in T Cell ALL
Is NCT05289687 recruiting? Yes, currently enrolling (Jun 2026). This Phase 2 trial studies multiple treatments including Daratumumab / Hyaluronidase and Daratumumab / Hyaluronidase for t-cell acute lymphoblastic leukemia.
Treatment: Daratumumab / Hyaluronidase · Daratumumab / Hyaluronidase · Daratumumab / Hyaluronidase · Daratumumab / Hyaluronidase — In this study, the investigators are hypothesizing that daratumumab-hyaluronidase will effectively treat T-ALL in patients who have persistent or recurrent MRD following treatment with chemotherapy.
Check if I qualifyExtracted eligibility criteria
Treatments studied
Immunotherapy
Cancer type
Acute Lymphoblastic Leukemia
Performance status
ECOG 0–2(Ambulatory, capable of self-care)
Prior therapy
Must have received: intensive chemotherapy
must be in first or later hematologic CR or CRi after a minimum of 2 blocks of intensive chemotherapy
Lab requirements
Blood counts
ANC ≥ 750/μL; Platelets ≥ 75,000/μL
Kidney function
Creatinine ≤ 1.5 x institutional ULN or Creatinine Clearance > 30 ml/min
Liver function
Total or Direct bilirubin ≤ 2 mg/dL; AST(SGOT)/ALT(SGPT) ≤ 3.0 × institutional ULN
Cardiac function
NYHA Functional Classification class 2B or better
Absolute neutrophil count (ANC) ≥ 750/μL; Platelets ≥ 75,000/μL; Total or Direct bilirubin ≤ 2 mg/dL; AST(SGOT)/ALT(SGPT) ≤ 3.0 × institutional ULN; Creatinine ≤ 1.5 x institutional ULN or Creatinine Clearance > 30 ml/min; ... cardiac disease ... NYHA Functional Classification class 2B or better
Structured fields extracted by AI. May contain errors — verify against the official protocol.
US trial sites
- Northwestern · Chicago, Illinois
Showing up to 5 US sites.
See all sites on ClinicalTrials.gov →Frequently asked questions
Is NCT05289687 currently recruiting?
Yes, this trial is currently recruiting patients.
Is prior treatment required for enrollment?
Yes. Patients must have previously received intensive chemotherapy.
Could you qualify for this trial?
Enter your biomarker results to see how this trial's eligibility criteria match your specific cancer profile.
Check if I qualifyRelated pages