OncoMatch/Clinical Trials/NCT05253495

Chemoradiotherapy With Targeted Immunotherapy in Pediatric Lymphoma

Is NCT05253495 recruiting? Yes, currently enrolling (Jun 2026). This Phase 2 trial studies multiple treatments for non-hodgkin lymphoma.

Phase 2RecruitingNew York Medical CollegeNCT05253495Data as of Jun 2026

Treatment: DOC Group B · Pv-COMRAD 1 and 2 Group B · Pv-R-CYM 1 and 2 Group B · DOC Group C · MAD CPR 1 and 2 · Pv-R CYVE 1 and 2 · Pv-R CYVE-MTX 1 and 2 · MAD CP · Pv-Cytarabine/etoposide · AD CP · Bv-AVD-R 1 and 2: COHORT IIa · Bv-NVD-R, Cycle 1-2 · Bv-NVD-R, Cycle 1-4 SER · Bv-AVD-R · Bv-NVD-R, Cycle 1-4 RER · Bv-NAVD-R, Cycle 1-2 — The addition of targeted immunotherapy will be safe and well tolerated and facilitate the reduction of anthracycline exposure while preserving lymphoma disease control in children, adolescents and young adults (CAYA) with mature B-cell non-Hodgkin lymphoma (MB-NHL) and classical Hodgkin lymphoma (cHL).

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Extracted eligibility criteria

Treatments studied

Other

DOC Group BPv-COMRAD 1 and 2 Group BPv-R-CYM 1 and 2 Group BDOC Group CMAD CPR 1 and 2Pv-R CYVE 1 and 2Pv-R CYVE-MTX 1 and 2MAD CPPv-Cytarabine/etoposideAD CPBv-AVD-R 1 and 2: COHORT IIaBv-NVD-R, Cycle 1-2Bv-NVD-R, Cycle 1-4 SERBv-AVD-RBv-NVD-R, Cycle 1-4 RERBv-NAVD-R, Cycle 1-2

Cancer type

Non-Hodgkin Lymphoma

Hodgkin Lymphoma

Disease stage

Required: Stage I, IIA, IIB, IIIA, IIIB, IV, III

COHORT Ia: stage III with LDH ≥ 2 ULN OR stage IV (5-24% bone marrow lymphoma infiltration) COHORT Ib: any CNS involvement and/or BM involvement (≥ 25% lymphoma cells) COHORT IIa: stage I-IIA with bulky ± E, I-IIB no bulky ± E, IIIA ± E (INTERMEDIATE RISK) COHORT IIb: stage IIB with bulky ± E, IIIA with bulky ± E, IIIB, IV (HIGH RISK)

Demographics

Ages 3–39

Prior therapy

No prior treatment (treatment-naive required)

Lab requirements

Blood counts

Kidney function

Liver function

Adequate organ function

Structured fields extracted by AI. May contain errors — verify against the official protocol.

US trial sites

University of Alabama · Birmingham, Alabama

Showing up to 5 US sites.

See all sites on ClinicalTrials.gov →

Frequently asked questions

Is NCT05253495 currently recruiting?

Yes, this trial is currently recruiting patients.

Can patients have received prior systemic therapy?

No. This trial requires treatment-naive patients — prior systemic therapy is an exclusion criterion.

What disease stage is eligible?

Stage I or IIA or IIB or IIIA or IIIB or IV or III is required.

Is there an age limit?

Yes. Patients must be 39 years or younger and at least 3 years old.

Could you qualify for this trial?

Enter your biomarker results to see how this trial's eligibility criteria match your specific cancer profile.

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Non-Hodgkin Lymphoma trials Hodgkin Lymphoma trials