OncoMatch/Clinical Trials/NCT05230680
Azacitidine-CHOP for Patients With Nodal T-cell Lymphoma With T-follicular Helper Phenotype (ACANTUS)
Is NCT05230680 recruiting? Yes, currently enrolling (May 2026). This Phase 1/2 trial studies ACHOP for t cell lymphoma.
Treatment: ACHOP — Induction treatment (every 3 weeks, total 6 cycles) * Azacitidine D-2, -1, 1 (level 1: 50mg/m2, level 2: 75mg/m2, level 3: 100mg/m2, level 4: 125mg/m2) * Cyclophosphamide 750mg/m2 d1 * Doxorubicin 50 mg/m2 d1 * Vincristine 1.4 mg/m2 (Max: 2 mg) d1 * Prednisolone 100mg PO d1-5 Maintenance treatment (every 4 weeks, total 12 cycles) * Azacitidine 75mg/m2 d1-5
Check if I qualifyExtracted eligibility criteria
Cancer type
Non-Hodgkin Lymphoma
Performance status
ECOG 0–2(Ambulatory, capable of self-care)
Prior therapy
Cannot have received: chemotherapy
Exception: short-term corticosteroids (for less than 8 days) prior to selection
Previously treated for T-cell lymphoma with immunotherapy or chemotherapy, except for short-term corticosteroids (for less than 8 days) prior to selection
Cannot have received: chemotherapy
History of chemotherapy for Hodgkin's or other non-Hodgkin's lymphoma in the last 5 years
Cannot have received: radiation therapy
Exception: localized to a single lymph node
Prior radiotherapy, except for those localized to a single lymph node
Cannot have received: doxorubicin (doxorubicin)
History of administration of doxorubicin at >200 mg/m²
Lab requirements
Blood counts
absolute neutrophil count (anc) ≥1,500/μl, platelets ≥100,000/μl (or anc ≥500/μl and platelets ≥50,000/ μl in the presence of bone marrow involvement)
Kidney function
serum cr ≤2.0mg/dl or egfr ≥ 30ml/min according to the cockroft-gault formula
Liver function
alt ≤2.5x upper limit of normal (uln) (or ≤5x uln in the presence of liver involvement), total bilirubin ≤2x uln (or ≤3x uln in the presence of liver involvement)
Cardiac function
lvef ≥45% on echocardiography or muga
Structured fields extracted by AI. May contain errors — verify against the official protocol.
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