OncoMatch/Clinical Trials/NCT05179889
Adjuvant mFOLFIRINOX for High-risk Stage III Colon Cancer
Is NCT05179889 recruiting? Yes, currently enrolling (Jun 2026). This Phase 2/3 trial studies multiple treatments including mFOLFIRINOX and mFOLFOX 6 for colon cancer stage iii.
Treatment: mFOLFIRINOX · mFOLFOX 6 — A multicenter, open labeled randomized, phase II trial comparing mFOLFIRINOX and mFOLFOX6 as adjuvant treatment for high risk stage III (pT4N1/2 or pTanyN2) colon cancer
Check if I qualifyExtracted eligibility criteria
Treatments studied
Other
Cancer type
Colorectal Cancer
Disease stage
Required: Stage III
Performance status
ECOG 0–2(Ambulatory, capable of self-care)
Demographics
Prior therapy
Must have received: surgery — curative radical resection (successful R0 resection) within 60 days before randomization
Curative radical resection (successful R0 resection) within 60 days before randomization
Lab requirements
Blood counts
ANC ≥ 2×10^6 cells/mL; hemoglobin ≥ 9.0 g/dL; platelets ≥ 100×10^6 cells/mL
Kidney function
serum creatinine ≤1.5 × ULN or creatinine clearance > 50 mL/min (Cockcroft-Gault formula)
Liver function
ALT/AST ≤2.5 × ULN; serum total bilirubin ≤ 1.5 ULN; alkaline phosphatase ≤ 2.5 × ULN
Adequate organ functions: ANC ≥ 2×10^6 cells/mL; Hemoglobin ≥ 9.0 g/dL; Platelets ≥ 100×10^6 cells/mL; ALT/AST ≤2.5 × ULN; serum total bilirubin ≤ 1.5 ULN; alkaline phosphatase ≤ 2.5 × ULN; serum creatinine ≤1.5 × ULN or creatinine clearance > 50 mL/min (Cockcroft-Gault formula)
Structured fields extracted by AI. May contain errors — verify against the official protocol.
Frequently asked questions
Is NCT05179889 currently recruiting?
Yes, this trial is currently recruiting patients.
Is prior treatment required for enrollment?
Yes. Patients must have previously received surgery.
What disease stage is eligible?
Stage III is required.
Is there an age limit?
Yes. Patients must be 75 years or younger and at least 20 years old.
Could you qualify for this trial?
Enter your biomarker results to see how this trial's eligibility criteria match your specific cancer profile.
Check if I qualifyRelated pages