OncoMatch/Clinical Trials/NCT05176665
EMB-01 in Patients With Advanced/Metastatic Gastrointestinal Cancers
Is NCT05176665 recruiting? Yes, currently enrolling (May 2026). This Phase 1/2 trial studies EMB-01 for neoplasms.
Treatment: EMB-01 — This study is to evaluate the safety and antitumor activity of EMB-01 in advanced/metastatic gastrointestinal cancers, including gastric cancer, hepatocellular cancer, cholangiocarcinoma and colorectal cancer.
Check if I qualifyExtracted eligibility criteria
Cancer type
Neuroendocrine Tumor
Biomarker criteria
Required: MET amplification
cMET amplification in tumor sample
Required: MET overexpression
cMET overexpression in tumor sample
Required: EGFR overexpression
EGFR overexpression in tumor sample
Required: EGFR gene alteration
Other EGFR ... gene alteration in blood sample (circulating tumor DNA, ctDNA)
Required: MET gene alteration
Other ... cMET gene alteration in blood sample (circulating tumor DNA, ctDNA)
Excluded: HER2 (ERBB2) gene alteration known to confer resistance to EGFR and/or cMET inhibitors
documented gene alteration including but not limited to HER2 ... that is known to confer resistance to EGFR and/or cMET inhibitors
Excluded: KRAS gene alteration known to confer resistance to EGFR and/or cMET inhibitors
documented gene alteration including but not limited to ... KRAS ... that is known to confer resistance to EGFR and/or cMET inhibitors
Excluded: NRAS gene alteration known to confer resistance to EGFR and/or cMET inhibitors
documented gene alteration including but not limited to ... NRAS ... that is known to confer resistance to EGFR and/or cMET inhibitors
Excluded: BRAF gene alteration known to confer resistance to EGFR and/or cMET inhibitors
documented gene alteration including but not limited to ... BRAF ... that is known to confer resistance to EGFR and/or cMET inhibitors
Excluded: NTRK1 gene alteration known to confer resistance to EGFR and/or cMET inhibitors
documented gene alteration including but not limited to ... NTRK ... that is known to confer resistance to EGFR and/or cMET inhibitors
Excluded: NTRK2 gene alteration known to confer resistance to EGFR and/or cMET inhibitors
documented gene alteration including but not limited to ... NTRK ... that is known to confer resistance to EGFR and/or cMET inhibitors
Excluded: NTRK3 gene alteration known to confer resistance to EGFR and/or cMET inhibitors
documented gene alteration including but not limited to ... NTRK ... that is known to confer resistance to EGFR and/or cMET inhibitors
Excluded: ALK gene alteration known to confer resistance to EGFR and/or cMET inhibitors
documented gene alteration including but not limited to ... ALK ... that is known to confer resistance to EGFR and/or cMET inhibitors
Excluded: RET gene alteration known to confer resistance to EGFR and/or cMET inhibitors
documented gene alteration including but not limited to ... RET ... that is known to confer resistance to EGFR and/or cMET inhibitors
Excluded: ROS1 gene alteration known to confer resistance to EGFR and/or cMET inhibitors
documented gene alteration including but not limited to ... ROS1 ... that is known to confer resistance to EGFR and/or cMET inhibitors
Excluded: FGFR1 gene alteration known to confer resistance to EGFR and/or cMET inhibitors
documented gene alteration including but not limited to ... FGFR ... that is known to confer resistance to EGFR and/or cMET inhibitors
Excluded: FGFR2 gene alteration known to confer resistance to EGFR and/or cMET inhibitors
documented gene alteration including but not limited to ... FGFR ... that is known to confer resistance to EGFR and/or cMET inhibitors
Excluded: FGFR3 gene alteration known to confer resistance to EGFR and/or cMET inhibitors
documented gene alteration including but not limited to ... FGFR ... that is known to confer resistance to EGFR and/or cMET inhibitors
Disease stage
Metastatic disease required
Performance status
ECOG 0–1(Restricted strenuous activity)
Prior therapy
Must have received: standard of care therapies
Have failed all standard of care therapies known to confer clinical benefit. Patients who is not tolerable on standard of care therapies, or no standard of care therapies available, or refused standard of care therapies are eligible.
Lab requirements
Blood counts
Kidney function
Liver function
Must have adequate organ function
Structured fields extracted by AI. May contain errors — verify against the official protocol.
US trial sites
- MD Anderson Cancer Center · Houston, Texas
Showing up to 5 US sites. See all sites on ClinicalTrials.gov →
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