OncoMatch/Clinical Trials/NCT05105152
PLAT-08: A Study Of SC-DARIC33 CAR T Cells In Pediatric And Young Adults With Relapsed Or Refractory CD33+ AML
Is NCT05105152 recruiting? Yes, currently enrolling (Jun 2026). This Phase 1 trial studies SC-DARIC33 for acute myeloid leukemia.
Treatment: SC-DARIC33 — A phase 1, open-label, non-randomized study enrolling pediatric and young adult patients with relapsed or refractory CD33+ leukemia with and without prior history of allogeneic hematopoietic cell transplantation, to examine the safety and feasibility of administering an autologous T cell product that has been genetically modified to express a Dimerizing Agent Regulated Immunoreceptor Complex (DARIC).
Check if I qualifyExtracted eligibility criteria
Treatments studied
Other
Cancer type
Acute Myeloid Leukemia
Biomarker criteria
Required: CD33 expression (positive by flow cytometry)
AML that expresses CD33 by flow cytometry
Demographics
Prior therapy
Cannot have received: virotherapy
Lab requirements
Kidney function
serum creatinine ≤ 1.5 x the upper limit of normal (uln)
Liver function
total bilirubin ≤ 3 times uln for age or conjugated bilirubin ≤ 2 mg/dl and alt (sgpt) ≤ 5 times uln
Cardiac function
shortening fraction ≥ 28% or ejection fraction ≥ 50% as measured by echocardiogram
Structured fields extracted by AI. May contain errors — verify against the official protocol.
US trial sites
- Seattle Children's Hospital · Seattle, Washington
Showing up to 5 US sites.
See all sites on ClinicalTrials.gov →Frequently asked questions
Is NCT05105152 currently recruiting?
Yes, this trial is currently recruiting patients.
Are there prior therapy exclusions?
Yes. Prior virotherapy disqualifies patients from enrollment.
Does this trial require CD33?
Yes, CD33 expression is a required biomarker for enrollment.
Is there an age limit?
Yes. Patients must be 30 years or younger.
Could you qualify for this trial?
Enter your biomarker results to see how this trial's eligibility criteria match your specific cancer profile.
Check if I qualifyRelated pages