OncoMatch/Clinical Trials/NCT05086250
Feasibility Study of Oral Ketamine Versus Placebo for the Treatment of Anxiety in Patients With Pancreatic Cancer
Is NCT05086250 recruiting? Yes, currently enrolling (May 2026). This Early Phase 1 trial studies multiple treatments including Ketamine and Ketamine for anxiety.
Treatment: Ketamine · Ketamine — This is a prospective, single center, double blind, randomized, crossover feasibility study of oral ketamine versus placebo for the treatment of anxiety in patients with pancreatic cancer currently receiving or within 12 weeks of receiving cancer targeted therapy. The primary objective is to determine the feasibility of enrolling subjects and treatment adherence. The secondary objectives are to describe the safety and tolerability. Exploratory objectives are to assess the effect of ketamine/placebo on Depression, Anxiety, Physical Function, Pain Interference, Pain Intensity, Fatigue, Sleep Disturbance, and Ability to Participate in Social Roles and Activities as measured by PROMIS Anxiety Short Form 7a and the PROMIS-29 Profile v2.1 of Patient Reported Outcomes, as well as changes in circulatory inflammatory cytokines, blood glutamine levels, and other biomarkers of anxiety and/or depression.
Check if I qualifyExtracted eligibility criteria
Cancer type
Pancreatic Cancer
Lab requirements
Liver function
Documented adequate liver function within the screening period.
Cardiac function
No severe cardiac insufficiency (NYHA III or IV), uncontrolled and/or unstable cardiac or coronary artery disease, current or recent significant tachyarrhythmia, severe angina, or myocardial ischemia.
Documented history of severe cardiac insufficiency (NYHA III or IV), with currently uncontrolled and/or unstable cardiac or coronary artery disease. Current or recent significant tachyarrhythmia, severe angina, or myocardial ischemia, as assessed by a study physician.
Structured fields extracted by AI. May contain errors — verify against the official protocol.
US trial sites
- Cedars-Sinai Medical Center · Los Angeles, California
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