OncoMatch/Clinical Trials/NCT05083754
Carmustine Wafer in Combination With Retifanlimab and Radiation With/Without Temozolomide in Subjects With Glioblastoma
Is NCT05083754 recruiting? Yes, currently enrolling (May 2026). This Phase 1 trial studies multiple treatments including Retifanlimab and Temozolomide for glioblastoma multiforme.
Treatment: Retifanlimab · Temozolomide — The purpose of the study is to evaluate the safety and survival of carmustine wafers and radiation and retifanlimab with or without temozolomide (TMZ) in newly-diagnosed adult subjects with glioblastoma multiform after carmustine wafer placement.
Check if I qualifyExtracted eligibility criteria
Cancer type
Glioblastoma
Disease stage
Required: Stage IV
Grade: iv (who)
Prior therapy
Must have received: surgical resection
No prior treatment for GBM other than surgical resection and carmustine wafer placement
Must have received: carmustine wafer
carmustine wafers placed at resection
Cannot have received: anti-PD-1 therapy
Prior treatment with an anti-PD-1, anti-PD-L1, anti-PD-L2, anti-CD137, anti-CTLA-4 antibody or any other antibody or drug specifically targeting T-cell co-stimulation or immune checkpoint pathways
Cannot have received: other anti-neoplastic medications/treatments including the Optune® device
Intent to use other anti-neoplastic medications/treatments including the Optune® device
Lab requirements
Blood counts
Must have normal organ and marrow function on routine laboratory tests
Kidney function
Must have normal organ and marrow function on routine laboratory tests
Liver function
Must have normal organ and marrow function on routine laboratory tests
Must have normal organ and marrow function on routine laboratory tests
Structured fields extracted by AI. May contain errors — verify against the official protocol.
US trial sites
- Johns Hopkins Medical Institution · Baltimore, Maryland
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