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OncoMatch/Clinical Trials/NCT05080946

Using Aspirin to Improve Immunological Features of Ovarian Tumors

Is NCT05080946 recruiting? Yes, currently enrolling (May 2026). This Early Phase 1 trial studies Aspirin 325mg for ovarian cancer.

Early Phase 1RecruitingH. Lee Moffitt Cancer Center and Research InstituteNCT05080946Data as of May 2026

Treatment: Aspirin 325mg — The purpose of the study is to evaluate the effectiveness of aspirin with neoadjuvant chemotherapy for decreasing markers of immune suppression in the tumor at interval debulking surgery, in women with diagnosed ovarian, fallopian tube, or peritoneal carcinoma

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Extracted eligibility criteria

Cancer type

Ovarian Cancer

Performance status

ECOG 0–2(Ambulatory, capable of self-care)

Prior therapy

No prior treatment (treatment-naive required)
Max 0 prior lines

Lab requirements

Blood counts

Un-transfused platelet count > 100,000 cells/μL; Absolute neutrophil count > 1.5 x 10^9 cells/L; Hemoglobin > 9.0 g/dL, may use transfusions and the value can be post-transfusion

Kidney function

Estimated creatinine clearance of > 30 mL/min, calculated using the formula Cockcroft-Gault

Liver function

No severe hepatic impairment defined as AST or ALT elevation < 2.5 x institutional ULN, unless liver metastasis is present < 5 x ULN

Un-transfused platelet count > 100,000 cells/μL; Absolute neutrophil count > 1.5 x 10^9 cells/L; Hemoglobin > 9.0 g/dL, may use transfusions and the value can be post-transfusion; Estimated creatinine clearance of > 30 mL/min, calculated using the formula Cockcroft-Gault; No severe hepatic impairment defined as AST or ALT elevation < 2.5 x institutional ULN, unless liver metastasis is present < 5 x ULN

Structured fields extracted by AI. May contain errors — verify against the official protocol.

US trial sites

  • Moffitt Cancer Center · Tampa, Florida
  • Oregon Health and Science University · Portland, Oregon
  • University of Virginia Comprehensive Cancer Center · Charlottesville, Virginia
  • Inova Schar Cancer Institute · Fairfax, Virginia

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