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OncoMatch/Clinical Trials/NCT05075980

Intensity Modulated Proton or X-Ray Therapy After Surgery for Treatment of Head and Neck Cancer, the HEADLIGHT Study

Is NCT05075980 recruiting? Yes, currently enrolling (May 2026). This Phase 2 trial studies Cisplatin for head and neck carcinoma.

Phase 2RecruitingMayo ClinicNCT05075980Data as of May 2026

Treatment: Cisplatin — This clinical trial studies how well intensity modulated proton therapy (IMPT) or intensity modulated X-ray (radiation) therapy (IMRT) works after surgery in treating patients with head and neck cancer. IMPT is a type of radiation therapy that allows for the most accurate application of proton radiation to the tumor and has the potential to reduce treatment-related side effects. IMRT is a type of 3-dimensional radiation therapy that uses computer-generated images to show the size and shape of the tumor. Thin beams of x-ray radiation of different intensities are aimed at the tumor from many angles. This type of radiation therapy reduces the damage to healthy tissue near the tumor. IMPT may work as well as IMRT after surgery in treating patients with head and neck cancer.

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Extracted eligibility criteria

Cancer type

Head and Neck Squamous Cell Carcinoma

Tumor Agnostic

Biomarker criteria

Required: HPV wild-type

Diagnosis requires confirmation of p16 and/or HPV DNA negativity for oropharyngeal and unknown primary sites

Performance status

ECOG 0–1(Restricted strenuous activity)

Prior therapy

Cannot have received: radiation therapy

Prior radiation therapy that would have a clinically significant overlap with the intended head/neck radiation

Structured fields extracted by AI. May contain errors — verify against the official protocol.

US trial sites

  • Mayo Clinic Hospital in Arizona · Phoenix, Arizona
  • Mayo Clinic in Arizona · Scottsdale, Arizona
  • Mayo Clinic in Florida · Jacksonville, Florida
  • Mayo Clinic Health System in Albert Lea · Albert Lea, Minnesota
  • Mayo Clinic Health System - Mankato · Mankato, Minnesota

Showing up to 5 US sites. See all sites on ClinicalTrials.gov →

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