OncoMatch/Clinical Trials/NCT05030298
Preoperative Radiosurgery for the Treatment of High Grade Glioma, NeoGlioma Trial
Is NCT05030298 recruiting? Yes, currently enrolling (Jun 2026). This Phase 1 trial studies Temozolomide for malignant glioma.
Treatment: Temozolomide — This phase I trial finds out the possible benefits and/or side effects of radiosurgery before surgery (preoperative) in treating patients with high grade glioma. Radiosurgery uses special equipment to position the patient and precisely give a single large dose of radiation to the tumor. This method may kill tumor cells with fewer doses over a shorter period and cause less damage to normal tissue. Giving pre-operative radiosurgery may improve the odds of brain tumor control and reduce treatment-related side effects.
Check if I qualifyExtracted eligibility criteria
Treatments studied
Chemotherapy
Cancer type
Glioblastoma
Disease stage
Required: Stage WHO GRADE III, WHO GRADE IV (WHO)
Excluded: Stage WHO GRADE I, WHO GRADE II
World Health Organization [WHO] grade III-IV, including glioblastoma
Performance status
ECOG 0–2(Ambulatory, capable of self-care)
Prior therapy
Cannot have received: cranial radiotherapy
Prior history of cranial radiotherapy
Cannot have received: systemic anti-cancer therapy
Exception: within the previous 3 months
Use of systemic anti-cancer therapy within the previous 3 months
Structured fields extracted by AI. May contain errors — verify against the official protocol.
US trial sites
- Mayo Clinic in Arizona · Phoenix, Arizona
- Mayo Clinic in Florida · Jacksonville, Florida
Showing up to 5 US sites.
See all sites on ClinicalTrials.gov →Frequently asked questions
Is NCT05030298 currently recruiting?
Yes, this trial is currently recruiting patients.
Are there prior therapy exclusions?
Yes. Prior cranial radiotherapy, systemic anti-cancer therapy disqualifies patients from enrollment.
What disease stage is eligible?
Stage WHO GRADE III or WHO GRADE IV is required.
Could you qualify for this trial?
Enter your biomarker results to see how this trial's eligibility criteria match your specific cancer profile.
Check if I qualifyRelated pages