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OncoMatch/Clinical Trials/NCT04980716

Early Specialized Cardiovascular Intervention Based on Impedance Cardiography in Locally Advanced Non-small Cell Lung Cancer Patients

Is NCT04980716 recruiting? Yes, currently enrolling (Jun 2026). This Phase 3 trial studies Multiple cardiovascular drugs related to "Golden Triangle" for non-small cell lung cancer.

Phase 3RecruitingSun Yat-sen UniversityNCT04980716Data as of Jun 2026Location: China

Treatment: Multiple cardiovascular drugs related to "Golden Triangle"This is a prospective, randomized, controlled, multi-center phase III clinical trial that intends to evaluate the role of early cardiovascular intervention based on impedance cardiography in patients with locally advanced non-small cell lung cancer receiving radical radiochemotherapy±immunotherapy.

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Extracted eligibility criteria

Treatments studied

Other

Multiple cardiovascular drugs related to "Golden Triangle"

Cancer type

Non-Small Cell Lung Carcinoma

Disease stage

Required: Stage III

Performance status

WHO 0–1

Demographics

Ages ≤ 75

Lab requirements

Blood counts

absolute neutrophil count ≥1.5×10^9/L; platelets ≥100×10^9/L; hemoglobin ≥90 g/L

Kidney function

serum creatinine clearance calculated according to the Cockcroft-Gault formula ≥50 mL/min

Liver function

serum bilirubin ≤1.5 times ULN; alanine aminotransferase and aspartate aminotransferase ≤2.5 times ULN

Cardiac function

FEV1 ≥1000 ml

Organ and bone marrow function meet the following conditions: Forced expiratory volume per second (FEV1) ≥1000 ml; absolute neutrophil count ≥1.5×10^9/L; platelets ≥100×10^9/L; hemoglobin ≥90 g/L ; Serum creatinine clearance calculated according to the Cockcroft-Gault formula ≥50 mL/min (Cockcroft and Gault 1976); serum bilirubin ≤1.5 times the upper limit of normal (ULN); alanine aminotransferase and aspartate aminotransferase ≤2.5 times ULN

Structured fields extracted by AI. May contain errors — verify against the official protocol.

Frequently asked questions

Is NCT04980716 currently recruiting?

Yes, this trial is currently recruiting patients.

What disease stage is eligible?

Stage III is required.

Is there an age limit?

Yes. Patients must be 75 years or younger.

Could you qualify for this trial?

Enter your biomarker results to see how this trial's eligibility criteria match your specific cancer profile.

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