OncoMatch/Clinical Trials/NCT04973306
Neoadjuvant Immunotherapy Plus CRT Versus Neoadjuvant CRT for Locally Advanced Resectable ESCC
Is NCT04973306 recruiting? Yes, currently enrolling (Jun 2026). This Phase 2/3 trial studies Tislelizumab for esophageal squamous cell carcinoma stage ii.
Treatment: Tislelizumab — The purpose of this study was to evaluate the safety, feasibility and outcome of anti-PD-1 antibody (Tislelizumab, BeiGene) combined with neoadjuvant chemoradiotherapy versus neoadjuvant chemoradiotherapy followed by minimally invasive esophagectomy for locally advanced resectable esophageal squamous cell carcinoma (cII-III Stage) patient.
Check if I qualifyExtracted eligibility criteria
Treatments studied
Immunotherapy
Cancer type
Esophageal Carcinoma
Disease stage
Required: Stage II, III
Excluded: Stage CM+, CN3, CT4B, CTIS-1A, CT1BN0
Performance status
ECOG 0–1(Restricted strenuous activity)
Demographics
Prior therapy
Cannot have received: chemotherapy
Cannot have received: radiotherapy
Cannot have received: targeted therapy
Cannot have received: immunotherapy
Lab requirements
Blood counts
white blood cells >4x10^9 /l; neutrophil >2.0×10^9 /l; hemoglobin > 90 g/l; platelets>100x10^9 /l
Kidney function
glomerular filtration rate (ccr) >60 ml/min; serum creatinine (scr) ≤120 µmol/l
Liver function
total bilirubin <1.5x uln; ast and alt <1.5x uln
Cardiac function
all patients should perform ecg, and those with a cardiac history or ecg abnormality should perform echocardiography with the left ventricular ejection fraction > 50 %
Structured fields extracted by AI. May contain errors — verify against the official protocol.
Frequently asked questions
Is NCT04973306 currently recruiting?
Yes, this trial is currently recruiting patients.
Can patients have received prior systemic therapy?
No. This trial requires treatment-naive patients — prior systemic therapy is an exclusion criterion.
What disease stage is eligible?
Stage II or III is required.
Is there an age limit?
Yes. Patients must be 75 years or younger.
Could you qualify for this trial?
Enter your biomarker results to see how this trial's eligibility criteria match your specific cancer profile.
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