OncoMatch/Clinical Trials/NCT04966663
Using ctDNA to Determine Therapies for Lung Cancer
Is NCT04966663 recruiting? Yes, currently enrolling (May 2026). This Phase 2 trial studies multiple treatments for non small cell lung cancer.
Treatment: Nivolumab · Pemetrexed · Gemcitabine · Cisplatin · Carboplatin — This is a study to look at whether the presence of circulating tumour DNA (ctDNA) in the blood can help to predict whether giving adjuvant treatment after surgery can decrease the chance of the cancer coming back in people with lung cancer.
Check if I qualifyExtracted eligibility criteria
Cancer type
Small Cell Lung Cancer
Disease stage
Required: Stage T1-2N0M0
Complete surgical resection of T1-2N0M0 NSCLC or T3/T4 multifocal NSCLC
Performance status
ECOG 0–1(Restricted strenuous activity)
Prior therapy
Cannot have received: chemotherapy
No prior chemotherapy or radiotherapy is allowed for the current diagnosis of resected NSCLC.
Cannot have received: radiation therapy
No prior chemotherapy or radiotherapy is allowed for the current diagnosis of resected NSCLC.
Cannot have received: immune-mediated anti-cancer therapy (anti-CTLA-4, anti-PD-1, anti-PD-L1, nivolumab, agents targeting CD73, agents targeting CD39, agents targeting adenosine receptors)
Prior receipt of any immune-mediated anti-cancer therapy including, but not limited to, anti-CTLA-4, anti-PD-1, anti-PD-L1 antibodies including nivolumab and agents targeting CD73, CD39, or adenosine receptors
Cannot have received: conventional or investigational anticancer therapy
Receipt of any conventional or investigational anticancer therapy within 21 days or radiotherapy within 14 days prior to the scheduled first dose of study treatment
Lab requirements
Blood counts
Adequate organ and marrow function as defined in Table 4 (3.1.1)
Kidney function
Adequate organ and marrow function as defined in Table 4 (3.1.1)
Liver function
Adequate organ and marrow function as defined in Table 4 (3.1.1)
Adequate organ and marrow function as defined in Table 4 (3.1.1)
Structured fields extracted by AI. May contain errors — verify against the official protocol.
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