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OncoMatch/Clinical Trials/NCT04951947

JS-201 Combined With Lenvatinib in the Treatment of Small-cell Lung Cancer

Is NCT04951947 recruiting? Yes, currently enrolling (May 2026). This Phase 2 trial studies JS201 combine with Lenvatinib for small-cell lung cancer.

Phase 2RecruitingHunan Province Tumor HospitalNCT04951947Data as of May 2026

Treatment: JS201 combine with LenvatinibThis is a prospective, single-arm phase II clinical study to evaluate the efficacy and safety of JS-201 combined with lenvatinib in the treatment of small-cell lung cancer that has failed previous chemotherapy combined with PD-L1. The primary observational endpoint is ORR, and the secondary observational endpoint is PFS, OS. The intervention mode is JS201 300mg i.v Q2w, lenvatinib 8mg po. Qd.

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Extracted eligibility criteria

Cancer type

Non-Small Cell Lung Carcinoma

Disease stage

Required: Stage IV

Performance status

ECOG 0–1(Restricted strenuous activity)

Prior therapy

Min 1 prior line

Must have received: EC plus anti-PD-L1 therapy — first-line

The patient failed first-line EC+PD-L1 treatment

Structured fields extracted by AI. May contain errors — verify against the official protocol.

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