OncoMatch/Clinical Trials/NCT04947059
Effectiveness of an Immediate Postoperative Intravesical Instillation With Either Gemcitabine or Epirubicin in Patients With Urinary Bladder Cancer (Gemcitabine Epirubicin Normal SAline)
Is NCT04947059 recruiting? Yes, currently enrolling (May 2026). This Phase 3 trial studies multiple treatments including Gemcitabine Hydrochloride combined with continuous saline irrigation and Epirubicin Hydrochloride combined with continuous saline irrigation for bladder cancer.
Treatment: Gemcitabine Hydrochloride combined with continuous saline irrigation · Epirubicin Hydrochloride combined with continuous saline irrigation — The natural history of non-muscle-invasive bladder cancer is characterised by recurrence and progression. We compare the effectiveness of gemcitabine hydrochloride and epirubicin hydrochloride, in combination with continuous saline irrigation, as an immediate single intravesical instillation in the potential reduction of the disease recurrence as well as progression.
Check if I qualifyExtracted eligibility criteria
Cancer type
Urothelial Carcinoma
Disease stage
Excluded: Stage PT2
Performance status
ECOG 0–1(Restricted strenuous activity)
Prior therapy
Cannot have received: intravesical instillation of chemotherapeutic agent or BCG
Intravesical instillation of chemotherapeutic agent or BCG in the last 6 months before the transurethral resection of the bladder tumor
Cannot have received: pelvic radiotherapy
History of pelvic radiotherapy
Lab requirements
Blood counts
35% <Hct <52%; WBC ≥3000 / μL; 75000 <PLT <500000 / μL
Kidney function
Creat <2.2mg/dl
Liver function
Alkaline phosphatase, total bilirubin, SGOT, SGPT: values as high as 2 times above the upper normal limit
Creat <2.2mg/dl; 35% <Hct <52%; WBC ≥3000 / μL; 75000 <PLT <500000 / μL; Alkaline phosphatase, total bilirubin, SGOT, SGPT: values as high as 2 times above the upper normal limit
Structured fields extracted by AI. May contain errors — verify against the official protocol.
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