OncoMatch/Clinical Trials/NCT04931979
SRT in Combination With Pembrolizumab in Patients With Recurrent Prostate Cancer After Radical Prostatectomy
Is NCT04931979 recruiting? Yes, currently enrolling (May 2026). This Phase 2 trial studies Pembrolizumab for urologic cancer.
Treatment: Pembrolizumab — To evaluate the efficacy and safety of a pembrolizumab therapy of pembrolizumab in combination with standard salvage radiation therapy (SRT) in patients with biochemical recurrence (BCR) of prostate-specific antigen (PSA) persistence after radical prostatectomy (RP).
Check if I qualifyExtracted eligibility criteria
Cancer type
Tumor Agnostic
Disease stage
Grade: 78910 (gleason)
Performance status
ECOG 0–1(Restricted strenuous activity)
Prior therapy
Must have received: radical prostatectomy
after RP
Cannot have received: anti-PD-1/PD-L1/PD-L2 or co-inhibitory T-cell receptor therapy
Prior-therapy with an anti-PD-1, anti-PD-L1, or anti PD L2 agent or with an agent directed to another stimulatory or co-inhibitory T-cell receptor (e.g., CTLA-4, OX 40, CD137)
Cannot have received: systemic anti-cancer therapy (neo-adjuvant androgen deprivation therapy (ADT), secondary hormone ablation, taxan-based chemotherapy)
Prior systemic anti-cancer therapy including investigational agents within 4 weeks prior to registration (like neo-adjuvant androgen deprivation therapy (ADT), secondary hormone ablation or taxan-based chemotherapy)
Cannot have received: radiation therapy
Prior radiotherapy within 4 weeks before start of study medication
Lab requirements
Blood counts
adequate organ function as defined in clinical trial protocol (CTP) (Section 4)
Kidney function
adequate organ function as defined in clinical trial protocol (CTP) (Section 4)
Liver function
adequate organ function as defined in clinical trial protocol (CTP) (Section 4)
Patients with adequate organ function as defined in clinical trial protocol (CTP) (Section 4)
Structured fields extracted by AI. May contain errors — verify against the official protocol.
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