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OncoMatch/Clinical Trials/NCT04931979

SRT in Combination With Pembrolizumab in Patients With Recurrent Prostate Cancer After Radical Prostatectomy

Is NCT04931979 recruiting? Yes, currently enrolling (May 2026). This Phase 2 trial studies Pembrolizumab for urologic cancer.

Phase 2RecruitingProf. Dr. med. Christian GratzkeNCT04931979Data as of May 2026

Treatment: PembrolizumabTo evaluate the efficacy and safety of a pembrolizumab therapy of pembrolizumab in combination with standard salvage radiation therapy (SRT) in patients with biochemical recurrence (BCR) of prostate-specific antigen (PSA) persistence after radical prostatectomy (RP).

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Extracted eligibility criteria

Cancer type

Tumor Agnostic

Disease stage

Grade: 78910 (gleason)

Performance status

ECOG 0–1(Restricted strenuous activity)

Prior therapy

Must have received: radical prostatectomy

after RP

Cannot have received: anti-PD-1/PD-L1/PD-L2 or co-inhibitory T-cell receptor therapy

Prior-therapy with an anti-PD-1, anti-PD-L1, or anti PD L2 agent or with an agent directed to another stimulatory or co-inhibitory T-cell receptor (e.g., CTLA-4, OX 40, CD137)

Cannot have received: systemic anti-cancer therapy (neo-adjuvant androgen deprivation therapy (ADT), secondary hormone ablation, taxan-based chemotherapy)

Prior systemic anti-cancer therapy including investigational agents within 4 weeks prior to registration (like neo-adjuvant androgen deprivation therapy (ADT), secondary hormone ablation or taxan-based chemotherapy)

Cannot have received: radiation therapy

Prior radiotherapy within 4 weeks before start of study medication

Lab requirements

Blood counts

adequate organ function as defined in clinical trial protocol (CTP) (Section 4)

Kidney function

adequate organ function as defined in clinical trial protocol (CTP) (Section 4)

Liver function

adequate organ function as defined in clinical trial protocol (CTP) (Section 4)

Patients with adequate organ function as defined in clinical trial protocol (CTP) (Section 4)

Structured fields extracted by AI. May contain errors — verify against the official protocol.

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