OncoMatch/Clinical Trials/NCT04929223
A Study Evaluating the Safety and Efficacy of Targeted Therapies in Subpopulations of Patients With Metastatic Colorectal Cancer (INTRINSIC)
Is NCT04929223 recruiting? Yes, currently enrolling (May 2026). This Phase 1 trial studies multiple treatments for metastatic colorectal cancer.
Treatment: Inavolisib · Bevacizumab · Cetuximab · Atezolizumab · Tiragolumab · SY-5609 · Divarasib · FOLFOX · FOLFIRI — This open-label, exploratory study is designed to evaluate the safety and efficacy of targeted therapies or immunotherapy as single agents or combinations, in participants with metastatic colorectal cancer (mCRC) whose tumors are biomarker positive as per treatment arm-specific definition. Eligible participants with mCRC will be enrolled into specific treatment arms based on their biomarker assay results.
Check if I qualifyExtracted eligibility criteria
Cancer type
Colorectal Cancer
Disease stage
Metastatic disease required
Performance status
ECOG 0–1(Restricted strenuous activity)
Prior therapy
Must have received: systemic therapy for metastatic disease — metastatic
Prior therapies for metastatic disease
Cannot have received: systemic anti-cancer treatment
Any systemic anti-cancer treatment within 2 weeks or 5 half-lives (whichever is shorter) prior to start of study treatment
Cannot have received: investigational therapy
Treatment with investigational therapy within 28 days prior to initiation of study treatment
Lab requirements
Blood counts
Adequate hematologic function within 14 days prior to initiation of study treatment
Kidney function
Adequate organ function within 14 days prior to initiation of study treatment
Liver function
Adequate organ function within 14 days prior to initiation of study treatment
Adequate hematologic and organ function within 14 days prior to initiation of study treatment
Structured fields extracted by AI. May contain errors — verify against the official protocol.
US trial sites
- UAB Comprehensive Cancer Center · Birmingham, Alabama
- Mayo Clinic Arizona · Phoenix, Arizona
- City of Hope Comprehensive Cancer Center · Duarte, California
- cCare · Encinitas, California
- USC Norris Cancer Center · Los Angeles, California
Showing up to 5 US sites. See all sites on ClinicalTrials.gov →
Could you qualify for this trial?
Enter your biomarker results to see how this trial's eligibility criteria match your specific cancer profile.
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