OncoMatch/Clinical Trials/NCT04879043
Study to Assess Safety of HDP-101 in Patients With Relapsed Refractory Multiple Myeloma
Is NCT04879043 recruiting? Yes, currently enrolling (May 2026). This Phase 1/2 trial studies HDP-101 for multiple myeloma.
Treatment: HDP-101 — This study will assess the safety, tolerability, pharmacokinetics (PK) and the therapeutic potential of HDP-101 in patients with plasma cell disorders including multiple myeloma.
Check if I qualifyExtracted eligibility criteria
Cancer type
Multiple Myeloma
Performance status
ECOG 0–2(Ambulatory, capable of self-care)
Prior therapy
Must have received: immunomodulatory drug
prior treatments with antimyeloma therapy which must have included an immunomodulatory drug
Must have received: proteasome inhibitor
prior treatments with antimyeloma therapy which must have included ... proteasome inhibitor
Must have received: anti-CD38 treatment
prior treatments with antimyeloma therapy which must have included ... anti-CD38 treatment
Cannot have received: BCMA-targeting modalities
Exception: Phase 2a part only
For patient entering the Phase 2a part only: Prior treatment with any approved or experimental BCMA-targeting modalities are not allowed.
Cannot have received: autologous stem cell transplant
Exception: within 12 weeks before the first infusion or is planning for autologous SCT
Autologous or allogenic SCT within 12 weeks before the first infusion or is planning for autologous SCT.
Cannot have received: allogenic stem cell transplant
Exception: within 12 weeks before the first infusion
Autologous or allogenic SCT within 12 weeks before the first infusion
Cannot have received: radiation therapy
Exception: within 21 days prior to the first study treatment infusion
Radiotherapy within 21 days prior to the first study treatment infusion.
Lab requirements
Blood counts
Adequate organ system function as defined in protocol.
Kidney function
Adequate organ system function as defined in protocol.
Liver function
Adequate organ system function as defined in protocol.
Adequate organ system function as defined in protocol.
Structured fields extracted by AI. May contain errors — verify against the official protocol.
US trial sites
- Winship Cancer Institute of Emory University · Atlanta, Georgia
- Mount Sinai, The Tisch Cancer Instutute · New York, New York
- MD Anderson Cancer Center · Houston, Texas
Showing up to 5 US sites. See all sites on ClinicalTrials.gov →
Could you qualify for this trial?
Enter your biomarker results to see how this trial's eligibility criteria match your specific cancer profile.
Check if I qualify