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OncoMatch/Clinical Trials/NCT04879043

Study to Assess Safety of HDP-101 in Patients With Relapsed Refractory Multiple Myeloma

Is NCT04879043 recruiting? Yes, currently enrolling (May 2026). This Phase 1/2 trial studies HDP-101 for multiple myeloma.

Phase 1/2RecruitingHeidelberg Pharma AGNCT04879043Data as of May 2026

Treatment: HDP-101This study will assess the safety, tolerability, pharmacokinetics (PK) and the therapeutic potential of HDP-101 in patients with plasma cell disorders including multiple myeloma.

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Extracted eligibility criteria

Cancer type

Multiple Myeloma

Performance status

ECOG 0–2(Ambulatory, capable of self-care)

Prior therapy

Must have received: immunomodulatory drug

prior treatments with antimyeloma therapy which must have included an immunomodulatory drug

Must have received: proteasome inhibitor

prior treatments with antimyeloma therapy which must have included ... proteasome inhibitor

Must have received: anti-CD38 treatment

prior treatments with antimyeloma therapy which must have included ... anti-CD38 treatment

Cannot have received: BCMA-targeting modalities

Exception: Phase 2a part only

For patient entering the Phase 2a part only: Prior treatment with any approved or experimental BCMA-targeting modalities are not allowed.

Cannot have received: autologous stem cell transplant

Exception: within 12 weeks before the first infusion or is planning for autologous SCT

Autologous or allogenic SCT within 12 weeks before the first infusion or is planning for autologous SCT.

Cannot have received: allogenic stem cell transplant

Exception: within 12 weeks before the first infusion

Autologous or allogenic SCT within 12 weeks before the first infusion

Cannot have received: radiation therapy

Exception: within 21 days prior to the first study treatment infusion

Radiotherapy within 21 days prior to the first study treatment infusion.

Lab requirements

Blood counts

Adequate organ system function as defined in protocol.

Kidney function

Adequate organ system function as defined in protocol.

Liver function

Adequate organ system function as defined in protocol.

Adequate organ system function as defined in protocol.

Structured fields extracted by AI. May contain errors — verify against the official protocol.

US trial sites

  • Winship Cancer Institute of Emory University · Atlanta, Georgia
  • Mount Sinai, The Tisch Cancer Instutute · New York, New York
  • MD Anderson Cancer Center · Houston, Texas

Showing up to 5 US sites. See all sites on ClinicalTrials.gov →

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