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OncoMatch/Clinical Trials/NCT04877522

Asciminib Roll-over Study

Is NCT04877522 recruiting? Yes, currently enrolling (May 2026). This Phase 4 trial studies multiple treatments for chronic myelogenous leukemia.

Phase 4RecruitingNovartis PharmaceuticalsNCT04877522Data as of May 2026

Treatment: Asciminib single agent · Imatinib · Nilotinib · Bosutinib · Dasatinib · Asciminib single agent pediatric formulationThis is a long term safety study for patients who have completed a Novartis sponsored asciminib study and are judged by the investigator to benefit from continued treatment

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Extracted eligibility criteria

Cancer type

Chronic Myeloid Leukemia

Biomarker criteria

Required: BCR fusion

PH+ CML or PH+ ALL

Required: ABL1 fusion

PH+ CML or PH+ ALL

Prior therapy

Must have received: asciminib (asciminib) — currently receiving

currently receiving treatment with asciminib (single agent or in combination with imatinib, nilotinib or dasatinib)

Must have received: tyrosine kinase inhibitor (imatinib, nilotinib, bosutinib) — currently receiving

currently receiving treatment with ... imatinib, nilotinib or bosutinib alone

Cannot have received:

Participant has been discontinued from parent study treatment

Structured fields extracted by AI. May contain errors — verify against the official protocol.

US trial sites

  • Michigan Med University of Michigan · Ann Arbor, Michigan
  • Memorial Sloan Kettering · New York, New York
  • Oregon Health Sciences University · Portland, Oregon
  • Texas Oncology · Dallas, Texas
  • Uni Of TX MD Anderson Cancer Cntr · Houston, Texas

Showing up to 5 US sites. See all sites on ClinicalTrials.gov →

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