OncoMatch/Clinical Trials/NCT04864054
T-Cell Therapy (ECT204) in Adults With Advanced HCC
Is NCT04864054 recruiting? Yes, currently enrolling (May 2026). This Phase 1/2 trial studies ECT204 T cells for hepatocellular carcinoma.
Treatment: ECT204 T cells — This is an open-label, dose escalation, multi-center, Phase I/II clinical trial aimed at assessing the safety and preliminary efficacy of an investigational ARTEMIS® ECT204 T-cell therapy. The trial is suitable for adult subjects (≥ 18 years of age) diagnosed with GPC3-positive HCC, who have failed or not tolerated at least two (2) different anti-HCC systemic agents.
Check if I qualifyExtracted eligibility criteria
Cancer type
Hepatocellular Carcinoma
Biomarker criteria
Required: GPC3 positive (IHC ≥10-20% tumor cells, ≥2+ (dose-escalation cohort); IHC ≥50% tumor cells, 2+/3+ (RP2D cohort))
GPC3-positive tumor expression confirmed by immunohistochemistry (IHC). For the dose-escalation cohort: ≥10-20% tumor cells, ≥2+ IHC. Beginning with the RP2D confirmatory cohort: ≥ 50% tumor cells, 2+/3+ IHC.
Prior therapy
Must have received: anti-HCC systemic agent
Must have failed, or not tolerated, at least two (2) different anti-HCC systemic agents.
Cannot have received: liver tumor-directed therapy
Exception: must be >14 days from date of consent
Currently receiving or ending (< 14 days from date of consent) liver tumor-directed therapy (e.g., radiation, ablation, embolization), or hepatic surgery.
Lab requirements
Liver function
Child-Pugh score of A6 or better.
Child-Pugh score of A6 or better. Adequate organ function.
Structured fields extracted by AI. May contain errors — verify against the official protocol.
US trial sites
- City of Hope · Duarte, California
- Kansas University Medical Center, Principal Investigator: · Westwood, Kansas
- Roswell Park Comprehensive Cancer Center · Buffalo, New York
- Oregon Health and Sciences University · Portland, Oregon
- University of Texas Southwestern, Harold C. Simmons Comprehensive Cancer Center · Dallas, Texas
Showing up to 5 US sites. See all sites on ClinicalTrials.gov →
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