OncoMatch/Clinical Trials/NCT04789681
Canakinumab for the Prevention of Lung Cancer, the Can-Prevent-Lung Trial
Is NCT04789681 recruiting? Yes, currently enrolling (May 2026). This Phase 2 trial studies Canakinumab for lung carcinoma.
Treatment: Canakinumab — This phase II trial studies the effects of canakinumab in preventing lung cancer in patients who have high-risk pulmonary nodules. Canakinumab is a monoclonal antibody that may interfere with the ability of tumor cells to grow and spread. Giving canakinumab may prevent the development of lung cancer.
Check if I qualifyExtracted eligibility criteria
Cancer type
Non-Small Cell Lung Carcinoma
Disease stage
Required: Stage I, IA1, IA2, IA3, IB, II, IIA, IIB, III, IIIA, IIIB, IIIC
Performance status
ECOG 0–1(Restricted strenuous activity)
Prior therapy
Must have received: curative intent therapy
Patients with history of stage I-III non-small cell lung cancer (NSCLC), who have completed treatment with curative intent
Cannot have received: anti-IL1beta
Has received prior therapy with an anti-IL1beta
Lab requirements
Blood counts
ANC ≥ 1500/uL; Platelets ≥ 100,000/uL; Hemoglobin ≥ 9.0 g/dL or ≥ 5.6 mmol/L (without erythropoietin dependency and without packed red blood cell transfusion within last 2 weeks)
Kidney function
Creatinine ≤ 1.5 x ULN OR measured or calculated creatinine clearance (CrCl) ≥ 30 mL/min for participant with creatinine levels > 1.5 x institutional ULN
Liver function
Total bilirubin ≤ 1.5 x ULN OR direct bilirubin ≤ ULN for participants with total bilirubin levels > 1.5 x ULN; AST and ALT ≤ 2.5 x ULN
Absolute neutrophil count (ANC) ≥ 1500/uL ... Platelets ≥ 100 000/uL ... Hemoglobin ≥ 9.0 g/dL or ≥ 5.6 mmol/L ... Creatinine ≤ 1.5 x ULN OR measured or calculated creatinine clearance ... Total bilirubin ≤ 1.5 x ULN OR direct bilirubin ≤ ULN ... AST and ALT ≤ 2.5 x ULN
Structured fields extracted by AI. May contain errors — verify against the official protocol.
US trial sites
- M D Anderson Cancer Center · Houston, Texas
Showing up to 5 US sites. See all sites on ClinicalTrials.gov →
Could you qualify for this trial?
Enter your biomarker results to see how this trial's eligibility criteria match your specific cancer profile.
Check if I qualify