OncoMatch/Clinical Trials/NCT04787744
Veterans Affairs Seamless Phase II/III Randomized Trial of STAndard Systemic theRapy With or Without PET-directed Local Therapy for Oligometastatic pRosTate Cancer
Is NCT04787744 recruiting? Yes, currently enrolling (May 2026). This Phase 2/3 trial studies multiple treatments for prostate cancer.
Treatment: Goserelin, Histrelin, Leuprolide & Triptorelin · ADT + Nilutamide, Flutamide, & Bicalutamide · Degarelix & Relugolix · ADT + Docetaxel +/- prednisone · ADT + Abiraterone + Prednisone · ADT + Abiraterone + Methylprednisolone · ADT + Apalutamide · ADT + Enzalutamide — This is a prospective, open-label, multi-center seamless phase II to phase III randomized clinical trial designed to compare SST with or without PET-directed local therapy in improving the castration-resistant prostate cancer-free survival (CRPC-free survival) for Veterans with oligometastatic prostate cancer. Oligometastasis will be defined as 1-10 sites of metastatic disease based on the clinical determination of the LSI which incorporates all imaging, clinical, and pathologic data available.
Check if I qualifyExtracted eligibility criteria
Cancer type
Prostate Cancer
Performance status
ECOG 0–2(Ambulatory, capable of self-care)
Prior therapy
Must have received: curative-intent local therapy — all sites of prostate cancer
If recurrent, prior curative-intent local therapy to all sites of prostate cancer with either upfront radiotherapy or prostatectomy with or without post-operative radiotherapy.
Cannot have received: radiation therapy
Exception: if prior radiation therapy to any sites requiring PET-directed local therapy or salvage local therapy will lead to prohibitively high risk of toxicity from subsequent local therapy, as determined by the treating radiation oncologist or surgeon/urologist
Prior radiation therapy to any sites requiring PET-directed local therapy or salvage local therapy that will lead to prohibitively high risk of toxicity from subsequent local therapy, as determined by the treating radiation oncologist (if radiation is intended as the study local therapy) or surgeon/urologist (if surgery is intended as the study local therapy).
Structured fields extracted by AI. May contain errors — verify against the official protocol.
US trial sites
- VA Long Beach Healthcare System, Long Beach, CA · Long Beach, California
- VA Greater Los Angeles Healthcare System, West Los Angeles, CA · West Los Angeles, California
- Washington DC VA Medical Center, Washington, DC · Washington D.C., District of Columbia
- Bay Pines VA Healthcare System, Pay Pines, FL · Bay Pines, Florida
- Edward Hines Jr. VA Hospital, Hines, IL · Hines, Illinois
Showing up to 5 US sites. See all sites on ClinicalTrials.gov →
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