OncoMatch/Clinical Trials/NCT04787354
Optimal Duration of Oxaliplatin in Adjuvant XELOX for Gastric Cancer Patients (EXODOX)
Is NCT04787354 recruiting? Yes, currently enrolling (Jun 2026). This Phase 3 trial studies multiple treatments including Oxaliplatin and Capecitabine for gastric cancer.
Treatment: Oxaliplatin · Capecitabine — This study aims to compare the efficacy and safety of reduced adjuvant XELOX treatment (4 cycles of XELOX followed by 4 cycles of capecitabine alone) to standard adjuvant XELOX treatment (8 cycles of XELOX).
Check if I qualifyExtracted eligibility criteria
Treatments studied
Chemotherapy
Cancer type
Gastric Cancer
Disease stage
Required: Stage II, III
Performance status
ECOG 0–2(Ambulatory, capable of self-care)
Demographics
Prior therapy
Cannot have received: systemic chemotherapy
Prior systemic chemotherapy or radiation therapy for stomach cancer
Cannot have received: radiation therapy
Prior systemic chemotherapy or radiation therapy for stomach cancer
Lab requirements
Blood counts
ANC > 1,500/uL, Platelet >100,000/uL, Hb > 8.0 g/dL (patients with chronic anemia who require intermittent blood transfusions can also participate)
Kidney function
serum creatinine < 1.5 x upper limit of normal (ULN)
Liver function
serum total bilirubin ≤ 1.5 x ULN, ALT and AST ≤ 3 x ULN
Adequate marrow function (ANC > 1,500/uL, Platelet >100,000/uL, Hb > 8.0 g/dL, patients with chronic anemia who require intermittent blood transfusions can also participate in the study); Adequate renal function, with serum creatinine < 1.5 x upper limit of normal (ULN); Adequate hepatic function with serum total bilirubin ≤ 1.5 x ULN, alanine aminotransferase (ALT) and aspartate aminotransferase (AST) ≤ 3 x ULN
Structured fields extracted by AI. May contain errors — verify against the official protocol.
Frequently asked questions
Is NCT04787354 currently recruiting?
Yes, this trial is currently recruiting patients.
Can patients have received prior systemic therapy?
No. This trial requires treatment-naive patients — prior systemic therapy is an exclusion criterion.
What disease stage is eligible?
Stage II or III is required.
Could you qualify for this trial?
Enter your biomarker results to see how this trial's eligibility criteria match your specific cancer profile.
Check if I qualifyRelated pages