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OncoMatch/Clinical Trials/NCT04753879

Multi-agent Low Dose Chemotherapy GAX-CI Followed by Olaparib and Pembro in Metastatic Pancreatic Ductal Cancer.

Is NCT04753879 recruiting? Yes, currently enrolling (May 2026). This Phase 2 trial studies multiple treatments for metastatic pancreatic cancer.

Phase 2RecruitingSidney Kimmel Comprehensive Cancer Center at Johns HopkinsNCT04753879Data as of May 2026

Treatment: Nab-paclitaxel · Gemcitabine · Cisplatin · Irinotecan · Capecitabine · Pembrolizumab · OlaparibThe purpose of this study is to evaluate the safety and clinical activity of maintenance olaparib and pembrolizumab following multi-agent, low dose chemotherapy with gemcitabine, nab-paclitaxel, capecitabine, cisplatin, and irinotecan (GAX-CI) in patients with untreated metastatic pancreatic ductal cancer.

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Extracted eligibility criteria

Cancer type

Pancreatic Cancer

Disease stage

Metastatic disease required

Performance status

ECOG 0–1(Restricted strenuous activity)

Prior therapy

No prior treatment (treatment-naive required)
Max 0 prior lines

Cannot have received: chemotherapy

Had chemotherapy within 5 years prior to study treatment

Cannot have received: investigational drug

Have received any investigational drugs within 28 days prior to study treatment

Cannot have received: anti-PD-1 therapy

Has received prior therapy with an anti-PD-1, anti-PD-L1, or anti PD L2 agent

Cannot have received: chemotherapy (gemcitabine, nab-paclitaxel, capecitabine, cisplatin, irinotecan)

Has received prior therapy with gemcitabine, nab-paclitaxel, capecitabine, cisplatin, irinotecan, or PARP inhibitor

Cannot have received: PARP inhibitor

Has received prior therapy with gemcitabine, nab-paclitaxel, capecitabine, cisplatin, irinotecan, or PARP inhibitor

Cannot have received: radiation therapy

Has received radiotherapy for pancreatic cancer

Lab requirements

Blood counts

adequate organ and marrow function defined by study - specified laboratory tests

Kidney function

adequate organ and marrow function defined by study - specified laboratory tests

Liver function

adequate organ and marrow function defined by study - specified laboratory tests

Structured fields extracted by AI. May contain errors — verify against the official protocol.

US trial sites

  • Sidney Kimmel Comprehensive Cancer Center · Baltimore, Maryland

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