OncoMatch/Clinical Trials/NCT04753879
Multi-agent Low Dose Chemotherapy GAX-CI Followed by Olaparib and Pembro in Metastatic Pancreatic Ductal Cancer.
Is NCT04753879 recruiting? Yes, currently enrolling (May 2026). This Phase 2 trial studies multiple treatments for metastatic pancreatic cancer.
Treatment: Nab-paclitaxel · Gemcitabine · Cisplatin · Irinotecan · Capecitabine · Pembrolizumab · Olaparib — The purpose of this study is to evaluate the safety and clinical activity of maintenance olaparib and pembrolizumab following multi-agent, low dose chemotherapy with gemcitabine, nab-paclitaxel, capecitabine, cisplatin, and irinotecan (GAX-CI) in patients with untreated metastatic pancreatic ductal cancer.
Check if I qualifyExtracted eligibility criteria
Cancer type
Pancreatic Cancer
Disease stage
Metastatic disease required
Performance status
ECOG 0–1(Restricted strenuous activity)
Prior therapy
Cannot have received: chemotherapy
Had chemotherapy within 5 years prior to study treatment
Cannot have received: investigational drug
Have received any investigational drugs within 28 days prior to study treatment
Cannot have received: anti-PD-1 therapy
Has received prior therapy with an anti-PD-1, anti-PD-L1, or anti PD L2 agent
Cannot have received: chemotherapy (gemcitabine, nab-paclitaxel, capecitabine, cisplatin, irinotecan)
Has received prior therapy with gemcitabine, nab-paclitaxel, capecitabine, cisplatin, irinotecan, or PARP inhibitor
Cannot have received: PARP inhibitor
Has received prior therapy with gemcitabine, nab-paclitaxel, capecitabine, cisplatin, irinotecan, or PARP inhibitor
Cannot have received: radiation therapy
Has received radiotherapy for pancreatic cancer
Lab requirements
Blood counts
adequate organ and marrow function defined by study - specified laboratory tests
Kidney function
adequate organ and marrow function defined by study - specified laboratory tests
Liver function
adequate organ and marrow function defined by study - specified laboratory tests
Structured fields extracted by AI. May contain errors — verify against the official protocol.
US trial sites
- Sidney Kimmel Comprehensive Cancer Center · Baltimore, Maryland
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